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- W2000592075 abstract "The effect of lowering pulmonary blood flow and activating the complement system on white blood cell uptake and release by the lung was studied in anesthetized dogs. Seven animals served as controls, six received cobra venom factor to activate the complement system, six received cobra venom factor after pulmonary blood flow was increased by epinephrine, and five received cobra venom factor after pulmonary blood flow was lowered by inflating a balloon catheter in the inferior vena cava. Leukocyte cell and differential counts were determined on blood sample from the right ventricle and the root of the aorta. Under conditions of normal and increased cardiac output, intravenous injection of 1 mL cobra venom factor (64 U) was associated with a marked fall in polymorphonuclear leukocytes to approximately 55% of control levels while lymphocyte counts were unchanged. Lowering pulmonary blood flow by ballon inflation in the inferior vena cava caused the white blood cell count to fall to 39 ± 9% of the control value in the aorta and 55 ± 11% of control values in the right ventricle. Following cobra venom factor injection these fell further to 22 ± 7% and 35 ± 7%. Blood gases, postmortem pulmonary extravascular water, and histology did not differ from the control group in any of the experiments. We conclude that transient pulmonary leukocyte sequestration produced by lowering pulmonary blood flow and activation of the complement system is not associated with significant lung injury in dogs." @default.
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- W2000592075 date "1986-12-01" @default.
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- W2000592075 title "Transient sequestration of polymorphonuclear leukocytes in the lung is not associated with pulmonary injury in dogs" @default.
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- W2000592075 doi "https://doi.org/10.1016/s0883-9441(86)80002-8" @default.
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