FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000593366> ?p ?o ?g. }

• W2000593366 endingPage "n/a" @default.
• W2000593366 startingPage "n/a" @default.
• W2000593366 abstract "It is well established that cells exposed to the limiting oxygen microenvironment (hypoxia) of tumors acquire resistance to chemotherapy, through mechanisms not fully understood. We noted that a large number of cell lines showed protection from apoptotic stimuli, staurosporine, or etoposide, when exposed to long-term hypoxia (72 h). In addition, these cells had unusual enlarged mitochondria that were induced in a HIF-1-dependent manner. Enlarged mitochondria were functional as they conserved their transmembrane potential and ATP production. Here we reveal that mitochondria of hypoxia-induced chemotherapy-resistant cells undergo a HIF-1-dependent and mitofusin-1-mediated change in morphology from a tubular network to an enlarged phenotype. An imbalance in mitochondrial fusion/fission occurs since silencing of not only the mitochondrial fusion protein mitofusin 1 but also BNIP3 and BNIP3L, two mitochondrial HIF-targeted genes, reestablished a tubular morphology. Hypoxic cells were insensitive to staurosporine- and etoposide-induced cell death, but the silencing of mitofusin, BNIP3, and BNIP3L restored sensitivity. Our results demonstrate that some cancer cells have developed yet another way to evade apoptosis in hypoxia, by inducing mitochondrial fusion and targeting BNIP3 and BNIP3L to mitochondrial membranes, thereby giving these cells a selective growth advantage." @default.
• W2000593366 created "2016-06-24" @default.
• W2000593366 creator A5011577448 @default.
• W2000593366 creator A5024010111 @default.
• W2000593366 creator A5025518725 @default.
• W2000593366 creator A5026633562 @default.
• W2000593366 creator A5068152097 @default.
• W2000593366 creator A5091254505 @default.
• W2000593366 date "2009-01-01" @default.
• W2000593366 modified "2023-10-17" @default.
• W2000593366 title "Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli" @default.
• W2000593366 cites W1686385174 @default.
• W2000593366 cites W1965827991 @default.
• W2000593366 cites W1984337575 @default.
• W2000593366 cites W1989540421 @default.
• W2000593366 cites W1995025616 @default.
• W2000593366 cites W1995417238 @default.
• W2000593366 cites W1996830477 @default.
• W2000593366 cites W2000624133 @default.
• W2000593366 cites W2002321863 @default.
• W2000593366 cites W2006534323 @default.
• W2000593366 cites W2007706445 @default.
• W2000593366 cites W2017575850 @default.
• W2000593366 cites W2019818579 @default.
• W2000593366 cites W2023542615 @default.
• W2000593366 cites W2042062304 @default.
• W2000593366 cites W2056688967 @default.
• W2000593366 cites W2061114093 @default.
• W2000593366 cites W2069635784 @default.
• W2000593366 cites W2071229320 @default.
• W2000593366 cites W2073095545 @default.
• W2000593366 cites W2082575834 @default.
• W2000593366 cites W2097007474 @default.
• W2000593366 cites W2098902167 @default.
• W2000593366 cites W2099954870 @default.
• W2000593366 cites W2104954806 @default.
• W2000593366 cites W2112245889 @default.
• W2000593366 cites W2116184358 @default.
• W2000593366 cites W2124140045 @default.
• W2000593366 cites W2130758099 @default.
• W2000593366 cites W2158535498 @default.
• W2000593366 doi "https://doi.org/10.1002/jcp.21984" @default.
• W2000593366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19957303" @default.
• W2000593366 hasPublicationYear "2009" @default.
• W2000593366 type Work @default.
• W2000593366 sameAs 2000593366 @default.
• W2000593366 citedByCount "61" @default.
• W2000593366 countsByYear W20005933662012 @default.
• W2000593366 countsByYear W20005933662013 @default.
• W2000593366 countsByYear W20005933662014 @default.
• W2000593366 countsByYear W20005933662015 @default.
• W2000593366 countsByYear W20005933662016 @default.
• W2000593366 countsByYear W20005933662017 @default.
• W2000593366 countsByYear W20005933662018 @default.
• W2000593366 countsByYear W20005933662019 @default.
• W2000593366 countsByYear W20005933662020 @default.
• W2000593366 countsByYear W20005933662021 @default.
• W2000593366 countsByYear W20005933662022 @default.
• W2000593366 countsByYear W20005933662023 @default.
• W2000593366 crossrefType "journal-article" @default.
• W2000593366 hasAuthorship W2000593366A5011577448 @default.
• W2000593366 hasAuthorship W2000593366A5024010111 @default.
• W2000593366 hasAuthorship W2000593366A5025518725 @default.
• W2000593366 hasAuthorship W2000593366A5026633562 @default.
• W2000593366 hasAuthorship W2000593366A5068152097 @default.
• W2000593366 hasAuthorship W2000593366A5091254505 @default.
• W2000593366 hasConcept C104317684 @default.
• W2000593366 hasConcept C119056186 @default.
• W2000593366 hasConcept C121608353 @default.
• W2000593366 hasConcept C13591479 @default.
• W2000593366 hasConcept C163950672 @default.
• W2000593366 hasConcept C173358068 @default.
• W2000593366 hasConcept C185592680 @default.
• W2000593366 hasConcept C190283241 @default.
• W2000593366 hasConcept C195794163 @default.
• W2000593366 hasConcept C24586158 @default.
• W2000593366 hasConcept C2777092462 @default.
• W2000593366 hasConcept C2777591492 @default.
• W2000593366 hasConcept C2779084600 @default.
• W2000593366 hasConcept C28859421 @default.
• W2000593366 hasConcept C31573885 @default.
• W2000593366 hasConcept C54355233 @default.
• W2000593366 hasConcept C55493867 @default.
• W2000593366 hasConcept C62478195 @default.
• W2000593366 hasConcept C75385678 @default.
• W2000593366 hasConcept C86803240 @default.
• W2000593366 hasConcept C95444343 @default.
• W2000593366 hasConcept C96232424 @default.
• W2000593366 hasConceptScore W2000593366C104317684 @default.
• W2000593366 hasConceptScore W2000593366C119056186 @default.
• W2000593366 hasConceptScore W2000593366C121608353 @default.
• W2000593366 hasConceptScore W2000593366C13591479 @default.
• W2000593366 hasConceptScore W2000593366C163950672 @default.
• W2000593366 hasConceptScore W2000593366C173358068 @default.
• W2000593366 hasConceptScore W2000593366C185592680 @default.
• W2000593366 hasConceptScore W2000593366C190283241 @default.
• W2000593366 hasConceptScore W2000593366C195794163 @default.
• W2000593366 hasConceptScore W2000593366C24586158 @default.

• next