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• W2000593581 abstract "Context: The insulin receptor-related receptor (IRR) is an orphan receptor belonging to the insulin receptor (IR) family. Despite its unknown function, the specific tissue expression and the high sequence homology with the IR and the insulin-like growth factor 1 receptor (IGF1R) suggest a biological role in β-cells.Objectives: In this study we investigated the influence of a stimulatable IRR-tyrosine kinase on major IR/IGF1R signaling pathways and on proliferation and apoptosis of INS-1E β-cells.Methods: INS-1E cells were stably transfected with a colony stimulating factor 1 receptor (CSF1R)/IRR construct activated by a macrophage colony stimulating factor.Results and conclusion: After stimulation the construct showed time and dose dependent autophosphorylation and transient extracellular signal regulated kinase 1/2 activation. Protein kinase b was not phosphorylated and also an effect on proliferation and apoptosis of INS-1E could not be demonstrated. Thus, no obvious biologic function of the IRR is present in INS-1E β-cells." @default.
• W2000593581 created "2016-06-24" @default.
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• W2000593581 date "2010-06-10" @default.
• W2000593581 modified "2023-09-25" @default.
• W2000593581 title "Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1Eβ-cells" @default.
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• W2000593581 doi "https://doi.org/10.3109/13813455.2010.494671" @default.
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