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- W2000593698 abstract "Semliki Forest Virus (SFV) is an enveloped alphavirus that infects cells by a low-pH-dependent membrane fusion reaction. SFV fusion is catalyzed by the spike protein E1 subunit, which contains a putative fusion peptide between residues 79 and 97. Prior mutagenesis studies demonstrated that an E1 G91D mutation blocks both virus-membrane fusion and the formation of a highly stable E1 trimer believed to be a critical fusion intermediate. We have here demonstrated that the G91D mutant was also inactive in hemifusion, suggesting that the E1 homotrimer is important in the initial stages of lipid mixing. Revertant analysis of a G91 deletion mutant indicated that G91 was crucial for the viability of SFV. In contrast, a G83D mutation produced infectious virus with both efficient fusion and homotrimer formation. Thus, the G83 position, although highly conserved among alphaviruses, was functional if replaced with a charged amino acid." @default.
- W2000593698 created "2016-06-24" @default.
- W2000593698 creator A5068488671 @default.
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- W2000593698 date "2001-01-01" @default.
- W2000593698 modified "2023-09-27" @default.
- W2000593698 title "Differential Roles of Two Conserved Glycine Residues in the Fusion Peptide of Semliki Forest Virus" @default.
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- W2000593698 doi "https://doi.org/10.1006/viro.2000.0688" @default.
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