Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000594516> ?p ?o ?g. }
- W2000594516 endingPage "73" @default.
- W2000594516 startingPage "61" @default.
- W2000594516 abstract "Atg9 is a transmembrane protein essential for autophagy which cycles between the Golgi network, late endosomes and LC3-positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and requires the activity of the class III phosphatidylinositol-3-kinase (PI3KC3). In this study, we demonstrate that the N-BAR-containing protein, Bif-1, is required for Atg9 trafficking and the fission of Golgi membranes during the induction of autophagy. Upon starvation, Atg9-positive membranes undergo continuous tubulation and fragmentation to produce cytoplasmic punctate structures that are positive for Rab5, Atg16L and LC3. Loss of Bif-1 or inhibition of the PI3KC3 complex II suppresses starvation-induced fission of Golgi membranes and peripheral cytoplasmic redistribution of Atg9. Moreover, Bif-1 mutants, which lack the functional regions of the N-BAR domain that are responsible for membrane binding and/or bending activity, fail to restore the fission of Golgi membranes as well as the formation of Atg9 foci and autophagosomes in Bif-1-deficient cells starved of nutrients. Taken together, these findings suggest that Bif-1 acts as a critical regulator of Atg9 puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation." @default.
- W2000594516 created "2016-06-24" @default.
- W2000594516 creator A5008501255 @default.
- W2000594516 creator A5025004423 @default.
- W2000594516 creator A5025430347 @default.
- W2000594516 creator A5030893624 @default.
- W2000594516 creator A5032107158 @default.
- W2000594516 creator A5036428305 @default.
- W2000594516 creator A5050154369 @default.
- W2000594516 creator A5059706312 @default.
- W2000594516 date "2011-01-01" @default.
- W2000594516 modified "2023-10-17" @default.
- W2000594516 title "Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy" @default.
- W2000594516 cites W1986303112 @default.
- W2000594516 cites W1987414455 @default.
- W2000594516 cites W1991105254 @default.
- W2000594516 cites W1994823455 @default.
- W2000594516 cites W1999477136 @default.
- W2000594516 cites W2001591494 @default.
- W2000594516 cites W2005212835 @default.
- W2000594516 cites W2008417639 @default.
- W2000594516 cites W2008773520 @default.
- W2000594516 cites W2012040176 @default.
- W2000594516 cites W2026756449 @default.
- W2000594516 cites W2032601500 @default.
- W2000594516 cites W2041101236 @default.
- W2000594516 cites W2052403003 @default.
- W2000594516 cites W2055843777 @default.
- W2000594516 cites W2060309271 @default.
- W2000594516 cites W2062423108 @default.
- W2000594516 cites W2064042544 @default.
- W2000594516 cites W2066800765 @default.
- W2000594516 cites W2067692987 @default.
- W2000594516 cites W2071877471 @default.
- W2000594516 cites W2076166231 @default.
- W2000594516 cites W2078527512 @default.
- W2000594516 cites W2095187475 @default.
- W2000594516 cites W2100978111 @default.
- W2000594516 cites W2109034822 @default.
- W2000594516 cites W2109167860 @default.
- W2000594516 cites W2110736758 @default.
- W2000594516 cites W2110866976 @default.
- W2000594516 cites W2112323649 @default.
- W2000594516 cites W2113892331 @default.
- W2000594516 cites W2114847797 @default.
- W2000594516 cites W2115886998 @default.
- W2000594516 cites W2116690588 @default.
- W2000594516 cites W2117649547 @default.
- W2000594516 cites W2132763961 @default.
- W2000594516 cites W2135194969 @default.
- W2000594516 cites W2143013308 @default.
- W2000594516 cites W2144718635 @default.
- W2000594516 cites W2161050915 @default.
- W2000594516 cites W2161234475 @default.
- W2000594516 cites W2162378963 @default.
- W2000594516 cites W2165191318 @default.
- W2000594516 doi "https://doi.org/10.4161/auto.7.1.14015" @default.
- W2000594516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3039731" @default.
- W2000594516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21068542" @default.
- W2000594516 hasPublicationYear "2011" @default.
- W2000594516 type Work @default.
- W2000594516 sameAs 2000594516 @default.
- W2000594516 citedByCount "151" @default.
- W2000594516 countsByYear W20005945162012 @default.
- W2000594516 countsByYear W20005945162013 @default.
- W2000594516 countsByYear W20005945162014 @default.
- W2000594516 countsByYear W20005945162015 @default.
- W2000594516 countsByYear W20005945162016 @default.
- W2000594516 countsByYear W20005945162017 @default.
- W2000594516 countsByYear W20005945162018 @default.
- W2000594516 countsByYear W20005945162019 @default.
- W2000594516 countsByYear W20005945162020 @default.
- W2000594516 countsByYear W20005945162021 @default.
- W2000594516 countsByYear W20005945162022 @default.
- W2000594516 countsByYear W20005945162023 @default.
- W2000594516 crossrefType "journal-article" @default.
- W2000594516 hasAuthorship W2000594516A5008501255 @default.
- W2000594516 hasAuthorship W2000594516A5025004423 @default.
- W2000594516 hasAuthorship W2000594516A5025430347 @default.
- W2000594516 hasAuthorship W2000594516A5030893624 @default.
- W2000594516 hasAuthorship W2000594516A5032107158 @default.
- W2000594516 hasAuthorship W2000594516A5036428305 @default.
- W2000594516 hasAuthorship W2000594516A5050154369 @default.
- W2000594516 hasAuthorship W2000594516A5059706312 @default.
- W2000594516 hasBestOaLocation W20005945161 @default.
- W2000594516 hasConcept C102747710 @default.
- W2000594516 hasConcept C119062480 @default.
- W2000594516 hasConcept C158617107 @default.
- W2000594516 hasConcept C190062978 @default.
- W2000594516 hasConcept C190283241 @default.
- W2000594516 hasConcept C203522944 @default.
- W2000594516 hasConcept C55493867 @default.
- W2000594516 hasConcept C57581600 @default.
- W2000594516 hasConcept C79879829 @default.
- W2000594516 hasConcept C86803240 @default.
- W2000594516 hasConcept C95444343 @default.
- W2000594516 hasConceptScore W2000594516C102747710 @default.
- W2000594516 hasConceptScore W2000594516C119062480 @default.