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- W2000595788 abstract "The effects of propranolol, pindolol and metoprolol on the modification of low density lipoprotein (LDL) by U937 monocyte-like cells, endothelial cells and copper ions were studied by determination of the lipid peroxidation product content and measurement of the relative electrophoretic mobility of the particle. Propanolol and pindolol inhibited LDL oxidation by U937 cells in a dose-dependent manner from 10 to 100 μM, whereas metoprolol had no effect. In the case of LDL modification by endothelial cells, all the three β-blockers were efficient within the same range of concentrations, and the order of potency was propranolol > pindolol > metoprolol. In vitro oxidation of LDL in the presence of copper ions was also inhibited by propranolol; pindolol and metoprolol had no significant protective effect in this system. These results concerning the inhibitory action of β-blockers were confirmed by testing the degradation of modified LDL by J774 macrophages. Although the concentrations of the drugs utilized in this study are relatively high, in long-term treatment β-blockers might accumulate in target tissues, and the protective effect of propanolol against LDL oxidation might be involved in its inhibitory action on atherosclerosis previously reported in animal models." @default.
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- W2000595788 date "1992-06-01" @default.
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- W2000595788 title "Lipophilic β-blockers inhibit monocyte and endothelial cell-mediated modification of low density lipoproteins" @default.
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- W2000595788 doi "https://doi.org/10.1016/0005-2760(92)90246-r" @default.
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