Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000596494> ?p ?o ?g. }
- W2000596494 endingPage "1227" @default.
- W2000596494 startingPage "1221" @default.
- W2000596494 abstract "Proteasomes consist of a proteolytic core called the 20 S particle and ancillary factors that regulate its activity in various ways. PA200 has been identified as a large (200 kDa) nuclear protein that stimulates proteasomal hydrolysis of peptides. To characterize its interaction with the 20 S core, we have visualized PA200-20 S complexes by electron microscopy. Monomers of PA200 bind to one or both ends of the 20 S core. Reconstructed in three dimensions to 23 Å resolution from cryo-electron micrographs of the singly bound complex, PA200 has an asymmetric dome-like structure with major and minor lobes. Taking into account previous bioinformatic analysis, it is likely to represent an irregular folding of an α-helical solenoid composed of HEAT-like repeats. PA200 makes contact with all α-subunits except α7, and this interaction induces an opening of the axial channel through the α-ring. Thus, the activation mechanism of PA200 is expressed via its allosteric effects on the 20 S core particle, perhaps facilitating release of digestion products or the entrance of substrates." @default.
- W2000596494 created "2016-06-24" @default.
- W2000596494 creator A5041170594 @default.
- W2000596494 creator A5041795453 @default.
- W2000596494 creator A5048846433 @default.
- W2000596494 creator A5053266372 @default.
- W2000596494 creator A5077603452 @default.
- W2000596494 creator A5090643634 @default.
- W2000596494 date "2005-03-01" @default.
- W2000596494 modified "2023-10-15" @default.
- W2000596494 title "The Axial Channel of the 20S Proteasome Opens Upon Binding of the PA200 Activator" @default.
- W2000596494 cites W1675243257 @default.
- W2000596494 cites W1947552193 @default.
- W2000596494 cites W1964227266 @default.
- W2000596494 cites W1965786392 @default.
- W2000596494 cites W1975460230 @default.
- W2000596494 cites W1985544638 @default.
- W2000596494 cites W1987262921 @default.
- W2000596494 cites W1996460413 @default.
- W2000596494 cites W1997581342 @default.
- W2000596494 cites W1999119754 @default.
- W2000596494 cites W1999741800 @default.
- W2000596494 cites W2001728435 @default.
- W2000596494 cites W2004316415 @default.
- W2000596494 cites W2005993899 @default.
- W2000596494 cites W2006158980 @default.
- W2000596494 cites W2008592040 @default.
- W2000596494 cites W2011457559 @default.
- W2000596494 cites W2021040301 @default.
- W2000596494 cites W2026332191 @default.
- W2000596494 cites W2031794174 @default.
- W2000596494 cites W2034564804 @default.
- W2000596494 cites W2040517780 @default.
- W2000596494 cites W2065065004 @default.
- W2000596494 cites W2085343528 @default.
- W2000596494 cites W2087019753 @default.
- W2000596494 cites W2089130084 @default.
- W2000596494 cites W2120580958 @default.
- W2000596494 cites W2123781000 @default.
- W2000596494 cites W2126467039 @default.
- W2000596494 cites W2145571109 @default.
- W2000596494 cites W2165102205 @default.
- W2000596494 cites W2166690788 @default.
- W2000596494 cites W2169536566 @default.
- W2000596494 cites W2178503716 @default.
- W2000596494 cites W4245819220 @default.
- W2000596494 cites W5111567 @default.
- W2000596494 doi "https://doi.org/10.1016/j.jmb.2004.12.049" @default.
- W2000596494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15713476" @default.
- W2000596494 hasPublicationYear "2005" @default.
- W2000596494 type Work @default.
- W2000596494 sameAs 2000596494 @default.
- W2000596494 citedByCount "98" @default.
- W2000596494 countsByYear W20005964942012 @default.
- W2000596494 countsByYear W20005964942013 @default.
- W2000596494 countsByYear W20005964942014 @default.
- W2000596494 countsByYear W20005964942015 @default.
- W2000596494 countsByYear W20005964942016 @default.
- W2000596494 countsByYear W20005964942017 @default.
- W2000596494 countsByYear W20005964942018 @default.
- W2000596494 countsByYear W20005964942019 @default.
- W2000596494 countsByYear W20005964942020 @default.
- W2000596494 countsByYear W20005964942021 @default.
- W2000596494 countsByYear W20005964942022 @default.
- W2000596494 crossrefType "journal-article" @default.
- W2000596494 hasAuthorship W2000596494A5041170594 @default.
- W2000596494 hasAuthorship W2000596494A5041795453 @default.
- W2000596494 hasAuthorship W2000596494A5048846433 @default.
- W2000596494 hasAuthorship W2000596494A5053266372 @default.
- W2000596494 hasAuthorship W2000596494A5077603452 @default.
- W2000596494 hasAuthorship W2000596494A5090643634 @default.
- W2000596494 hasConcept C119599485 @default.
- W2000596494 hasConcept C12554922 @default.
- W2000596494 hasConcept C127413603 @default.
- W2000596494 hasConcept C141315368 @default.
- W2000596494 hasConcept C14228908 @default.
- W2000596494 hasConcept C151730666 @default.
- W2000596494 hasConcept C166342909 @default.
- W2000596494 hasConcept C166940927 @default.
- W2000596494 hasConcept C170493617 @default.
- W2000596494 hasConcept C175156509 @default.
- W2000596494 hasConcept C178790620 @default.
- W2000596494 hasConcept C181199279 @default.
- W2000596494 hasConcept C185592680 @default.
- W2000596494 hasConcept C204328495 @default.
- W2000596494 hasConcept C20702342 @default.
- W2000596494 hasConcept C23265538 @default.
- W2000596494 hasConcept C27740335 @default.
- W2000596494 hasConcept C2776545253 @default.
- W2000596494 hasConcept C43369102 @default.
- W2000596494 hasConcept C47701112 @default.
- W2000596494 hasConcept C521977710 @default.
- W2000596494 hasConcept C55493867 @default.
- W2000596494 hasConcept C71240020 @default.
- W2000596494 hasConcept C8010536 @default.
- W2000596494 hasConcept C86803240 @default.
- W2000596494 hasConcept C88045685 @default.
- W2000596494 hasConceptScore W2000596494C119599485 @default.