FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000596495> ?p ?o ?g. }

• W2000596495 endingPage "13145" @default.
• W2000596495 startingPage "13141" @default.
• W2000596495 abstract "Brd4 is a double bromodomain-containing protein that binds preferentially to acetylated chromatin. It belongs to the BET (bromodomains and extraterminal) family that includes mammalian Brd2, Brd3, Brd4, Brdt, Drosophila Fsh, yeast Bdf1, Bdf2, and corresponding homologues in other species. Brd4 is essential for cellular growth and has been implicated in cell cycle control, DNA replication, and gene rearrangement found in t(15;19)-associated carcinomas. Recently, Brd4 has been found in several transcription complexes, including the general cofactor Mediator and the P-TEFb elongation factor, and is capable of stimulating HIV-1 transcription in a Tat-independent manner. In addition, Brd4 is used as a cellular adaptor by some animal and human papillomaviruses (HPV) for anchoring viral genomes to mitotic chromosomes. This tethering, mediated by Brd4 interaction with virus-encoded E2 protein, facilitates viral genome segregation during mitosis. Interestingly, Brd4 is also identified in a transcriptional silencing complex assembled by HPV E2 and turns out to be the long sought cellular corepressor that inhibits the expression of HPV-encoded E6 and E7 oncoproteins that antagonize p53 and pRB tumor suppressor activity, respectively. The dual role of Brd4 in gene activation and repression illustrates how a dynamic chromatin-binding adaptor is able to recruit distinct transcriptional regulators to modulate promoter activity through cell cycle progression." @default.
• W2000596495 created "2016-06-24" @default.
• W2000596495 creator A5002452221 @default.
• W2000596495 creator A5061431942 @default.
• W2000596495 date "2007-05-01" @default.
• W2000596495 modified "2023-10-11" @default.
• W2000596495 title "The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation" @default.
• W2000596495 cites W1963869546 @default.
• W2000596495 cites W1970518169 @default.
• W2000596495 cites W1973462980 @default.
• W2000596495 cites W1977109470 @default.
• W2000596495 cites W1980067469 @default.
• W2000596495 cites W1981624930 @default.
• W2000596495 cites W1990657900 @default.
• W2000596495 cites W1992127633 @default.
• W2000596495 cites W2005191189 @default.
• W2000596495 cites W2009631763 @default.
• W2000596495 cites W2016775797 @default.
• W2000596495 cites W2017261393 @default.
• W2000596495 cites W2018971124 @default.
• W2000596495 cites W2025669923 @default.
• W2000596495 cites W2040321376 @default.
• W2000596495 cites W2040608136 @default.
• W2000596495 cites W2043148368 @default.
• W2000596495 cites W2052692973 @default.
• W2000596495 cites W2056601517 @default.
• W2000596495 cites W2062796383 @default.
• W2000596495 cites W2080910217 @default.
• W2000596495 cites W2090788819 @default.
• W2000596495 cites W2093648584 @default.
• W2000596495 cites W2107911443 @default.
• W2000596495 cites W2111901894 @default.
• W2000596495 cites W2113054620 @default.
• W2000596495 cites W2127442777 @default.
• W2000596495 cites W2140765582 @default.
• W2000596495 cites W2147372875 @default.
• W2000596495 cites W2148682747 @default.
• W2000596495 cites W2152178694 @default.
• W2000596495 cites W2152979497 @default.
• W2000596495 cites W2153781919 @default.
• W2000596495 cites W2154446973 @default.
• W2000596495 cites W2154876786 @default.
• W2000596495 cites W2157749054 @default.
• W2000596495 cites W2158076143 @default.
• W2000596495 cites W2160281011 @default.
• W2000596495 cites W2161329609 @default.
• W2000596495 cites W2161880719 @default.
• W2000596495 cites W2164364036 @default.
• W2000596495 cites W2167653615 @default.
• W2000596495 cites W2168093476 @default.
• W2000596495 cites W2171262570 @default.
• W2000596495 cites W2181638332 @default.
• W2000596495 cites W88342265 @default.
• W2000596495 doi "https://doi.org/10.1074/jbc.r700001200" @default.
• W2000596495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329240" @default.
• W2000596495 hasPublicationYear "2007" @default.
• W2000596495 type Work @default.
• W2000596495 sameAs 2000596495 @default.
• W2000596495 citedByCount "551" @default.
• W2000596495 countsByYear W20005964952012 @default.
• W2000596495 countsByYear W20005964952013 @default.
• W2000596495 countsByYear W20005964952014 @default.
• W2000596495 countsByYear W20005964952015 @default.
• W2000596495 countsByYear W20005964952016 @default.
• W2000596495 countsByYear W20005964952017 @default.
• W2000596495 countsByYear W20005964952018 @default.
• W2000596495 countsByYear W20005964952019 @default.
• W2000596495 countsByYear W20005964952020 @default.
• W2000596495 countsByYear W20005964952021 @default.
• W2000596495 countsByYear W20005964952022 @default.
• W2000596495 countsByYear W20005964952023 @default.
• W2000596495 crossrefType "journal-article" @default.
• W2000596495 hasAuthorship W2000596495A5002452221 @default.
• W2000596495 hasAuthorship W2000596495A5061431942 @default.
• W2000596495 hasBestOaLocation W20005964951 @default.
• W2000596495 hasConcept C101762097 @default.
• W2000596495 hasConcept C104317684 @default.
• W2000596495 hasConcept C146777309 @default.
• W2000596495 hasConcept C150194340 @default.
• W2000596495 hasConcept C158448853 @default.
• W2000596495 hasConcept C167227067 @default.
• W2000596495 hasConcept C2777841055 @default.
• W2000596495 hasConcept C2779634854 @default.
• W2000596495 hasConcept C54355233 @default.
• W2000596495 hasConcept C64927066 @default.
• W2000596495 hasConcept C74401373 @default.
• W2000596495 hasConcept C83640560 @default.
• W2000596495 hasConcept C86339819 @default.
• W2000596495 hasConcept C86803240 @default.
• W2000596495 hasConcept C95444343 @default.
• W2000596495 hasConceptScore W2000596495C101762097 @default.
• W2000596495 hasConceptScore W2000596495C104317684 @default.
• W2000596495 hasConceptScore W2000596495C146777309 @default.
• W2000596495 hasConceptScore W2000596495C150194340 @default.
• W2000596495 hasConceptScore W2000596495C158448853 @default.
• W2000596495 hasConceptScore W2000596495C167227067 @default.
• W2000596495 hasConceptScore W2000596495C2777841055 @default.
• W2000596495 hasConceptScore W2000596495C2779634854 @default.

• next