Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000596690> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2000596690 endingPage "255" @default.
- W2000596690 startingPage "249" @default.
- W2000596690 abstract "One of the new strategies for the prevention of HIV acquisition is the use of microbicides such as topical microbicides including antimicrobial and antiviral peptides. Ideally, new drug candidates should kill pathogens without determent to the normal bacterial flora considered important in health; such as hydrogen peroxide producing Lactobacillus species. The antimicrobial peptides LL-37 and LSA-5 were studied to determine their spectrum of activity against bacterial pathogens and normal flora organisms. The effects of divalent cations at biologically relevant concentrations were determined. We show the synthetic lytic peptide LSA-5 and the naturally occurring peptides LL-37 inactivate Neisseria gonorrhoeae but are less active against many normal flora members such as Lactobacillus species. Biologically relevant concentrations of calcium and magnesium prevented killing of sensitive strains. LSA-5 is more potent than LL-37, both are inhibited from killing sensitive strains by calcium and magnesium. Strains of Lactobacillus iners were killed by both microbicides even in the presence of the divalent cations. Antimicrobial peptides, such as LSA-5, have good potential for use in prevention of sexually transmitted disease, if formulated to sequester calcium and magnesium present in biological fluids." @default.
- W2000596690 created "2016-06-24" @default.
- W2000596690 creator A5017547539 @default.
- W2000596690 creator A5024564522 @default.
- W2000596690 creator A5054522836 @default.
- W2000596690 date "2012-01-01" @default.
- W2000596690 modified "2023-10-03" @default.
- W2000596690 title "<i>In vitro</i> activity of cationic peptides against <i>Neisseria gonorrhoeae</i> and vaginal <i>Lactobacillus</i> species: The effect of divalent cations" @default.
- W2000596690 cites W1971642218 @default.
- W2000596690 cites W1990949770 @default.
- W2000596690 cites W1995430048 @default.
- W2000596690 cites W2015581889 @default.
- W2000596690 cites W2024246208 @default.
- W2000596690 cites W2026835141 @default.
- W2000596690 cites W2047160675 @default.
- W2000596690 cites W2058161924 @default.
- W2000596690 cites W2095874292 @default.
- W2000596690 cites W2096283909 @default.
- W2000596690 cites W2104135646 @default.
- W2000596690 cites W2106123323 @default.
- W2000596690 cites W2112589439 @default.
- W2000596690 cites W2121394492 @default.
- W2000596690 cites W2126516803 @default.
- W2000596690 cites W2138170968 @default.
- W2000596690 cites W2144985431 @default.
- W2000596690 cites W2145755615 @default.
- W2000596690 cites W2146302964 @default.
- W2000596690 cites W2156077795 @default.
- W2000596690 cites W2160043086 @default.
- W2000596690 cites W2169759699 @default.
- W2000596690 cites W4237397003 @default.
- W2000596690 doi "https://doi.org/10.4236/abb.2012.33034" @default.
- W2000596690 hasPublicationYear "2012" @default.
- W2000596690 type Work @default.
- W2000596690 sameAs 2000596690 @default.
- W2000596690 citedByCount "7" @default.
- W2000596690 countsByYear W20005966902014 @default.
- W2000596690 countsByYear W20005966902016 @default.
- W2000596690 countsByYear W20005966902017 @default.
- W2000596690 countsByYear W20005966902020 @default.
- W2000596690 countsByYear W20005966902021 @default.
- W2000596690 countsByYear W20005966902022 @default.
- W2000596690 crossrefType "journal-article" @default.
- W2000596690 hasAuthorship W2000596690A5017547539 @default.
- W2000596690 hasAuthorship W2000596690A5024564522 @default.
- W2000596690 hasAuthorship W2000596690A5054522836 @default.
- W2000596690 hasBestOaLocation W20005966901 @default.
- W2000596690 hasConcept C100544194 @default.
- W2000596690 hasConcept C178790620 @default.
- W2000596690 hasConcept C185592680 @default.
- W2000596690 hasConcept C2776662696 @default.
- W2000596690 hasConcept C2779166590 @default.
- W2000596690 hasConcept C2779170986 @default.
- W2000596690 hasConcept C2780206646 @default.
- W2000596690 hasConcept C2780236403 @default.
- W2000596690 hasConcept C4937899 @default.
- W2000596690 hasConcept C519063684 @default.
- W2000596690 hasConcept C540938839 @default.
- W2000596690 hasConcept C55493867 @default.
- W2000596690 hasConcept C74884574 @default.
- W2000596690 hasConcept C86803240 @default.
- W2000596690 hasConcept C89423630 @default.
- W2000596690 hasConceptScore W2000596690C100544194 @default.
- W2000596690 hasConceptScore W2000596690C178790620 @default.
- W2000596690 hasConceptScore W2000596690C185592680 @default.
- W2000596690 hasConceptScore W2000596690C2776662696 @default.
- W2000596690 hasConceptScore W2000596690C2779166590 @default.
- W2000596690 hasConceptScore W2000596690C2779170986 @default.
- W2000596690 hasConceptScore W2000596690C2780206646 @default.
- W2000596690 hasConceptScore W2000596690C2780236403 @default.
- W2000596690 hasConceptScore W2000596690C4937899 @default.
- W2000596690 hasConceptScore W2000596690C519063684 @default.
- W2000596690 hasConceptScore W2000596690C540938839 @default.
- W2000596690 hasConceptScore W2000596690C55493867 @default.
- W2000596690 hasConceptScore W2000596690C74884574 @default.
- W2000596690 hasConceptScore W2000596690C86803240 @default.
- W2000596690 hasConceptScore W2000596690C89423630 @default.
- W2000596690 hasIssue "03" @default.
- W2000596690 hasLocation W20005966901 @default.
- W2000596690 hasOpenAccess W2000596690 @default.
- W2000596690 hasPrimaryLocation W20005966901 @default.
- W2000596690 hasRelatedWork W1895178838 @default.
- W2000596690 hasRelatedWork W2000596690 @default.
- W2000596690 hasRelatedWork W2011732773 @default.
- W2000596690 hasRelatedWork W2116141682 @default.
- W2000596690 hasRelatedWork W2122218171 @default.
- W2000596690 hasRelatedWork W2386349421 @default.
- W2000596690 hasRelatedWork W3206741701 @default.
- W2000596690 hasRelatedWork W4239106508 @default.
- W2000596690 hasRelatedWork W4254490357 @default.
- W2000596690 hasRelatedWork W4299507998 @default.
- W2000596690 hasVolume "03" @default.
- W2000596690 isParatext "false" @default.
- W2000596690 isRetracted "false" @default.
- W2000596690 magId "2000596690" @default.
- W2000596690 workType "article" @default.