Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000597679> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2000597679 endingPage "248" @default.
- W2000597679 startingPage "242" @default.
- W2000597679 abstract "13C-NMR with 13C-enriched taurine ([13C]taurine) has been utilized to study the formation and reactions of N-chlorotaurine in solution and in human cells. Taurine reacts instantaneously with HOCl at pH 7.0 to form N-chlorotaurine, which is stable in solution by itself. In the presence of α-amino acids, a chlorine transfer reaction taken place to produce N-chloroamino acids, which quickly convert to the corresponding aldehydes. [13C]Taurine was incubated with human neutrophils and with cultured human lymphoblastoid cells and 13C-NMR spectra of the whole cell mixtures were acquired in order to examine the formation of N-chlorotaurine from reaction between taurine and the endogenous HOCl produced by myeloperoxidase-catalyzed reactions (Zgliczynski, J.M., et al. (1968) Eur. J. Biochem. 4, 540; Weiss, S.J., et al. (1982) J. Clin. Invest. 70, 598). The presence of N-chlorotaurine in the cells was not detected on the 13C-NMR spectra. On the other hand, N-chloro[13C]taurine incubated with the cells was found to be converted to taurine, which must have been produced by a chlorine transfer reaction of the N-chlorotaurine to other cellular components such as amino acids, peptides or proteins. A 13C-NMR study of taurine uptake in human lymphoblastoid cells indicated that taurine is incorporated into a freely mobile intracellular pool. These results suggest that the presence of abundant taurine in a freely mobile intracellular pool may serve as a buffer in preventing oxidative damage to the cells from attacks by HOCl or other oxidants." @default.
- W2000597679 created "2016-06-24" @default.
- W2000597679 creator A5009580733 @default.
- W2000597679 creator A5034790721 @default.
- W2000597679 creator A5050558002 @default.
- W2000597679 creator A5060628867 @default.
- W2000597679 date "1988-05-01" @default.
- W2000597679 modified "2023-10-16" @default.
- W2000597679 title "13C-NMR study of taurine and chlorotaurine in human cells" @default.
- W2000597679 cites W109960168 @default.
- W2000597679 cites W1529776597 @default.
- W2000597679 cites W1552993337 @default.
- W2000597679 cites W1572386711 @default.
- W2000597679 cites W1574935324 @default.
- W2000597679 cites W1586360287 @default.
- W2000597679 cites W1933619914 @default.
- W2000597679 cites W1958167223 @default.
- W2000597679 cites W1969191376 @default.
- W2000597679 cites W1972182067 @default.
- W2000597679 cites W1997290215 @default.
- W2000597679 cites W1997785022 @default.
- W2000597679 cites W2020016431 @default.
- W2000597679 cites W2045017683 @default.
- W2000597679 cites W2051327380 @default.
- W2000597679 cites W2060640831 @default.
- W2000597679 cites W2067242583 @default.
- W2000597679 cites W2070667890 @default.
- W2000597679 cites W2085364296 @default.
- W2000597679 cites W2092959264 @default.
- W2000597679 cites W2116123190 @default.
- W2000597679 cites W2154658221 @default.
- W2000597679 cites W2154943112 @default.
- W2000597679 cites W2173087970 @default.
- W2000597679 doi "https://doi.org/10.1016/0167-4889(88)90058-4" @default.
- W2000597679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3370223" @default.
- W2000597679 hasPublicationYear "1988" @default.
- W2000597679 type Work @default.
- W2000597679 sameAs 2000597679 @default.
- W2000597679 citedByCount "18" @default.
- W2000597679 countsByYear W20005976792014 @default.
- W2000597679 countsByYear W20005976792020 @default.
- W2000597679 crossrefType "journal-article" @default.
- W2000597679 hasAuthorship W2000597679A5009580733 @default.
- W2000597679 hasAuthorship W2000597679A5034790721 @default.
- W2000597679 hasAuthorship W2000597679A5050558002 @default.
- W2000597679 hasAuthorship W2000597679A5060628867 @default.
- W2000597679 hasConcept C121332964 @default.
- W2000597679 hasConcept C1276947 @default.
- W2000597679 hasConcept C163111631 @default.
- W2000597679 hasConcept C185592680 @default.
- W2000597679 hasConcept C2777756961 @default.
- W2000597679 hasConcept C2779701627 @default.
- W2000597679 hasConcept C4839761 @default.
- W2000597679 hasConcept C515207424 @default.
- W2000597679 hasConcept C55493867 @default.
- W2000597679 hasConcept C67787023 @default.
- W2000597679 hasConcept C71240020 @default.
- W2000597679 hasConcept C79879829 @default.
- W2000597679 hasConceptScore W2000597679C121332964 @default.
- W2000597679 hasConceptScore W2000597679C1276947 @default.
- W2000597679 hasConceptScore W2000597679C163111631 @default.
- W2000597679 hasConceptScore W2000597679C185592680 @default.
- W2000597679 hasConceptScore W2000597679C2777756961 @default.
- W2000597679 hasConceptScore W2000597679C2779701627 @default.
- W2000597679 hasConceptScore W2000597679C4839761 @default.
- W2000597679 hasConceptScore W2000597679C515207424 @default.
- W2000597679 hasConceptScore W2000597679C55493867 @default.
- W2000597679 hasConceptScore W2000597679C67787023 @default.
- W2000597679 hasConceptScore W2000597679C71240020 @default.
- W2000597679 hasConceptScore W2000597679C79879829 @default.
- W2000597679 hasIssue "3" @default.
- W2000597679 hasLocation W20005976791 @default.
- W2000597679 hasLocation W20005976792 @default.
- W2000597679 hasOpenAccess W2000597679 @default.
- W2000597679 hasPrimaryLocation W20005976791 @default.
- W2000597679 hasRelatedWork W1972374909 @default.
- W2000597679 hasRelatedWork W2001222137 @default.
- W2000597679 hasRelatedWork W2012611403 @default.
- W2000597679 hasRelatedWork W2027096890 @default.
- W2000597679 hasRelatedWork W2060047302 @default.
- W2000597679 hasRelatedWork W2078034828 @default.
- W2000597679 hasRelatedWork W2093862856 @default.
- W2000597679 hasRelatedWork W2331093667 @default.
- W2000597679 hasRelatedWork W2362478129 @default.
- W2000597679 hasRelatedWork W2005404302 @default.
- W2000597679 hasVolume "969" @default.
- W2000597679 isParatext "false" @default.
- W2000597679 isRetracted "false" @default.
- W2000597679 magId "2000597679" @default.
- W2000597679 workType "article" @default.