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• W2000598375 abstract "The long-term consequences of impaired glucocorticoid receptor (GR) function on reward-related learning were studied in transgenic mice with impaired GR function in a series of experiments taxing conditioned and unconditioned approach responses to stimuli predictive of food. There was a double-dissociation in that transgenic mice with impaired GR activity showed enhanced conditioned exploration in situations when stimuli predicted reward, while free-feeding food consumption over 24 h was reduced. Previous experiments have shown altered accumbens dopaminergic activity in these animals. In line with these findings, we observed an enhanced behavioural stimulation of transgenic mice following administration of d-amphetamine (2 mg/kg). This suggests that the increase in preparatory responses in transgenic mice may be mediated via an enhanced accumbens dopaminergic activity, possibly secondary to alterations in other brain systems." @default.
• W2000598375 created "2016-06-24" @default.
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• W2000598375 date "1999-07-01" @default.
• W2000598375 modified "2023-09-23" @default.
• W2000598375 title "Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function" @default.
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• W2000598375 doi "https://doi.org/10.1016/s0166-4328(99)00003-0" @default.
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