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- W2000599085 abstract "As recently discussed 1 Rajewsky K. Nature. 1998; 394: 624-625 Crossref PubMed Scopus (26) Google Scholar , B cells can rearrange their immunoglobulin genes, even though they express a functional antibody molecule. In immature B cells this contributes to the maintenance of tolerance 2 Gay D. Saunders T. Camper S. Weigert M. J. Exp. Med. 1993; 177: 999-1008 Crossref PubMed Scopus (769) Google Scholar , 3 Tiegs S.L. Russell D.M. Nemazee D. J. Exp. Med. 1993; 177: 1009-1020 Crossref PubMed Scopus (861) Google Scholar . However, the adaptive advantage for mature B cells, which can undergo V(D)J recombination in vivo following antigenic stimulation 4 Han S. Dillon S.R. Zheng B. et al. Science. 1997; 278: 301-305 Crossref PubMed Scopus (251) Google Scholar , 5 Han S. Zheng B. Schatz D.G. Spanopoulou E. Kelsoe G. Science. 1996; 274: 2094-2097 Crossref PubMed Scopus (249) Google Scholar , 6 Papavasiliou F. Casellas R. Suh H. et al. Science. 1997; 278: 298-301 Crossref PubMed Scopus (209) Google Scholar , 7 Hikida M. Mori M. Takai T. et al. Science. 1996; 274: 2092-2094 Crossref PubMed Scopus (199) Google Scholar , is unclear. Ig rearrangement is unlikely to be involved in editing autoreactive B cells produced by somatic hypermutation, as the process is turned off by interaction with high affinity antigens 8 Hertz M. Kouskoff V. Nakamura T. Nemazee D. Nature. 1998; 394: 292-295 Crossref PubMed Scopus (104) Google Scholar . An alternative is that receptor editing provides an additional means of introducing diversity in B cells during the process of affinity maturation. However, this raises the question of what advantage there is in having such an additional process of receptor diversification." @default.
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- W2000599085 title "Receptor editing during affinity maturation" @default.
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- W2000599085 doi "https://doi.org/10.1016/s0167-5699(98)01408-x" @default.
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