FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000599573> ?p ?o ?g. }

• W2000599573 endingPage "153" @default.
• W2000599573 startingPage "145" @default.
• W2000599573 abstract "Interferons (IFN) are biological molecules with anti-viral, anti-proliferative and immunomodulatory actions. There is evidence that IFN-gamma increases the frequency of exacerbations of multiple sclerosis (MS) whereas IFN-beta may reduce their frequency. Here we present evidence that IFN-beta significantly decreases concanavalin A (Con A)-induced proliferation of peripheral blood mononuclear cells (PBMC) of MS patients and healthy individuals. Similar results were obtained when PBMC were activated through the T cell receptor (TcR) by anti-CD3 monoclonal antibody or independently of it by phorbol ester and Ca2+ ionophore. These effects of IFN-beta were also noted when IFN-gamma and IFN-beta were added together. Furthermore, IFN-beta decreased proliferation when added to cells that were already pre-activated. Activated CD4+ and CD8+ T cells were downregulated to approximately the same extent. Analysis of cytokine production showed that IFN-gamma production by Con A activated PBMC was increased in MS when compared to controls. IFN-beta significantly decreased IFN-gamma production in MS patients and control individuals. Con A activated cultures treated with IFN-beta showed decreased IL2R expression and accumulation of IL2. These results show that IFN-beta decreases T cell activation and IFN-gamma production in vitro, effects that may be beneficial in MS." @default.
• W2000599573 created "2016-06-24" @default.
• W2000599573 creator A5014137446 @default.
• W2000599573 creator A5040599717 @default.
• W2000599573 creator A5042335053 @default.
• W2000599573 date "1993-07-01" @default.
• W2000599573 modified "2023-09-26" @default.
• W2000599573 title "Interferon β decreases T cell activation and interferon γ production in multiple sclerosis" @default.
• W2000599573 cites W1515441361 @default.
• W2000599573 cites W1545898053 @default.
• W2000599573 cites W1666597578 @default.
• W2000599573 cites W1760041358 @default.
• W2000599573 cites W1963716433 @default.
• W2000599573 cites W1965618158 @default.
• W2000599573 cites W1967943532 @default.
• W2000599573 cites W1969837648 @default.
• W2000599573 cites W1972725262 @default.
• W2000599573 cites W1973706213 @default.
• W2000599573 cites W1975029709 @default.
• W2000599573 cites W1978345766 @default.
• W2000599573 cites W1982643652 @default.
• W2000599573 cites W1988031989 @default.
• W2000599573 cites W1990586830 @default.
• W2000599573 cites W1992389141 @default.
• W2000599573 cites W2000665475 @default.
• W2000599573 cites W2002265763 @default.
• W2000599573 cites W2003651898 @default.
• W2000599573 cites W2006257738 @default.
• W2000599573 cites W2010247030 @default.
• W2000599573 cites W2020737415 @default.
• W2000599573 cites W2025392129 @default.
• W2000599573 cites W2035722336 @default.
• W2000599573 cites W2039611848 @default.
• W2000599573 cites W2043856037 @default.
• W2000599573 cites W2050106089 @default.
• W2000599573 cites W2053322315 @default.
• W2000599573 cites W2056958245 @default.
• W2000599573 cites W2057549315 @default.
• W2000599573 cites W2059324307 @default.
• W2000599573 cites W2066433792 @default.
• W2000599573 cites W2070267239 @default.
• W2000599573 cites W2075142824 @default.
• W2000599573 cites W2076290236 @default.
• W2000599573 cites W2078355705 @default.
• W2000599573 cites W2082769143 @default.
• W2000599573 cites W2085374906 @default.
• W2000599573 cites W2091584540 @default.
• W2000599573 cites W2092289292 @default.
• W2000599573 cites W2094944875 @default.
• W2000599573 cites W2101803122 @default.
• W2000599573 cites W2109577352 @default.
• W2000599573 cites W2126360069 @default.
• W2000599573 cites W2135271960 @default.
• W2000599573 cites W2139070714 @default.
• W2000599573 cites W2142177598 @default.
• W2000599573 cites W2154766201 @default.
• W2000599573 cites W2157584173 @default.
• W2000599573 cites W2319014405 @default.
• W2000599573 cites W2329559050 @default.
• W2000599573 doi "https://doi.org/10.1016/0165-5728(93)90244-s" @default.
• W2000599573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8360326" @default.
• W2000599573 hasPublicationYear "1993" @default.
• W2000599573 type Work @default.
• W2000599573 sameAs 2000599573 @default.
• W2000599573 citedByCount "261" @default.
• W2000599573 countsByYear W20005995732012 @default.
• W2000599573 countsByYear W20005995732013 @default.
• W2000599573 countsByYear W20005995732014 @default.
• W2000599573 countsByYear W20005995732015 @default.
• W2000599573 countsByYear W20005995732016 @default.
• W2000599573 countsByYear W20005995732017 @default.
• W2000599573 countsByYear W20005995732018 @default.
• W2000599573 countsByYear W20005995732019 @default.
• W2000599573 countsByYear W20005995732020 @default.
• W2000599573 countsByYear W20005995732021 @default.
• W2000599573 countsByYear W20005995732022 @default.
• W2000599573 countsByYear W20005995732023 @default.
• W2000599573 crossrefType "journal-article" @default.
• W2000599573 hasAuthorship W2000599573A5014137446 @default.
• W2000599573 hasAuthorship W2000599573A5040599717 @default.
• W2000599573 hasAuthorship W2000599573A5042335053 @default.
• W2000599573 hasConcept C137061746 @default.
• W2000599573 hasConcept C147483822 @default.
• W2000599573 hasConcept C167672396 @default.
• W2000599573 hasConcept C185592680 @default.
• W2000599573 hasConcept C19869320 @default.
• W2000599573 hasConcept C199360897 @default.
• W2000599573 hasConcept C202751555 @default.
• W2000599573 hasConcept C203014093 @default.
• W2000599573 hasConcept C2776090121 @default.
• W2000599573 hasConcept C2776174256 @default.
• W2000599573 hasConcept C2776178377 @default.
• W2000599573 hasConcept C2778690821 @default.
• W2000599573 hasConcept C2780640218 @default.
• W2000599573 hasConcept C2780841837 @default.
• W2000599573 hasConcept C2908698914 @default.
• W2000599573 hasConcept C2994247566 @default.
• W2000599573 hasConcept C41008148 @default.

• next