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• W2000600286 abstract "A kinetic Monte Carlo simulation was developed using the deterministic reaction network developed by the Mann laboratory for tissue-factor (TF)-initiated blood coagulation. The model predicted thrombin dynamics in recalcified whole blood (3-fold diluted) pretreated with convulxin (platelet GPVI activator) and picomolar levels of TF (0–14 p<i>M</i>). The model did not accurately predict coagulation times at low TF (0–0.7 p<i>M</i>). The simulation revealed that ∼0.2 p<i>M</i> TF was the critical concentration to cause 50% of reactions containing 3-fold diluted whole blood to reach a clotting threshold of 0.05 U/ml thrombin by 1 h. Simulations of 1 nl of blood (5 p<i>M</i> TF) revealed small stochastic variations in thrombin initiation time, while 16.6 pl simulations were highly stochastic at this level of TF (50 molecules/16.6 pl). Further experiment and simulation will require evaluation of mechanisms of coagulation kinetics at subpicomolar levels of TF." @default.
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• W2000600286 date "2005-01-01" @default.
• W2000600286 modified "2023-09-27" @default.
• W2000600286 title "Stochastic Modeling of Blood Coagulation Initiation" @default.
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• W2000600286 doi "https://doi.org/10.1159/000089929" @default.
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