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- W2000600983 abstract "In our search for genes involved in oyster immunity we isolated a cDNA encoding a polypeptide closely related to the mammalian IκB kinase (IKK) family. IKK proteins play a central role in cell signaling by regulating nuclear factor‐κB (NF‐κB) activation. We report here the cloning of an oyster IKK‐like protein (oIKK) which possesses the characteristic organization of the mammalian IKK proteins, namely an amino‐terminal kinase domain followed by a leucine zipper region and a carboxyl‐terminal helix‐loop‐helix motif. When transfected into human cell lines, oIKK activated the expression of NF‐κB‐controlled reporter gene, whereas transfections with mutants of oIKK deleted within the kinase domain or within the helix‐loop‐helix motif respectively abolished and greatly reduced reporter gene activation. These results indicate that oIKK can replace the hIKK‐α in catalyzing NF‐κB nuclear translocation, and in triggering gene expression. Our results sustain the concept of an evolutionarily conserved signaling machinery in which IKK plays a major role." @default.
- W2000600983 created "2016-06-24" @default.
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- W2000600983 date "1999-06-23" @default.
- W2000600983 modified "2023-09-26" @default.
- W2000600983 title "Oyster IKK-like protein shares structural and functional properties with its mammalian homologues" @default.
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- W2000600983 doi "https://doi.org/10.1016/s0014-5793(99)00737-1" @default.
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