FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000604019> ?p ?o ?g. }

• W2000604019 endingPage "3101" @default.
• W2000604019 startingPage "3094" @default.
• W2000604019 abstract "A very unusual triple structural transition pattern below room temperature was observed for the antifilarial drug diethylcarbamazine citrate. Besides the first thermal, crystallographic, and vibrational investigations of this first-line drug used in clinical treatment for lymphatic filariasis, a noteworthy behavior with three structural transformations as a function of temperature was demonstrated by differential scanning calorimetry, Raman spectroscopy, and single-crystal X-ray diffractometry. Our X-ray data on single crystals allow for a complete featuring and understanding of all transitions, since the four structures associated with the three solid−solid phase transformations were accurately determined. Two of three structural transitions show an order−disorder mechanism and temperature hysteresis with exothermic peaks at 224 K (T1′) and 213 K (T2′) upon cooling and endothermic ones at 248 K (T1) and 226 K (T2) upon heating. The other transition occurs at 108 K (T3) and it is temperature-rate sensitive. Molecular displacements onto the (010) plane and conformational changes of the diethylcarbamazine backbone as a consequence of the C−H···N hydrogen bonding formation/cleavage between drug molecules explain the mechanism of the transitions at T1′/T2. However, such changes are observed only on alternate columns of the drug intercalated by citrate chains, which leads to a doubling of the lattice period along the a axis of the 235 K structure with respect to the 150 and 293 K structures. At T2′/T1, these structural alterations occur in all columns of the drug. At T3, there is a rotation on the axis of the N−C bond between the carbamoyl moiety and an ethyl group of one crystallographically independent diethylcarbamazine molecule besides molecular shifts and other conformational alterations. The impact of this study is based on the fascinating finding in which the versatile capability of structural adaptation dependent on the thermal history was observed for a relatively simple organic salt, diethylcarbamazine citrate." @default.
• W2000604019 created "2016-06-24" @default.
• W2000604019 creator A5000506024 @default.
• W2000604019 creator A5020699395 @default.
• W2000604019 creator A5032291094 @default.
• W2000604019 creator A5035998519 @default.
• W2000604019 creator A5065540866 @default.
• W2000604019 creator A5091169774 @default.
• W2000604019 date "2010-05-28" @default.
• W2000604019 modified "2023-10-03" @default.
• W2000604019 title "Triple Structural Transition below Room Temperature in the Antifilarial Drug Diethylcarbamazine Citrate" @default.
• W2000604019 cites W1539796472 @default.
• W2000604019 cites W1967251660 @default.
• W2000604019 cites W1968005767 @default.
• W2000604019 cites W1968250749 @default.
• W2000604019 cites W1971181330 @default.
• W2000604019 cites W1979229284 @default.
• W2000604019 cites W2021323508 @default.
• W2000604019 cites W2033559369 @default.
• W2000604019 cites W2051681187 @default.
• W2000604019 cites W2055748951 @default.
• W2000604019 cites W2055789080 @default.
• W2000604019 cites W2063334178 @default.
• W2000604019 cites W2064851541 @default.
• W2000604019 cites W2085182036 @default.
• W2000604019 cites W2099135305 @default.
• W2000604019 cites W2108021000 @default.
• W2000604019 cites W2166455137 @default.
• W2000604019 cites W2168630377 @default.
• W2000604019 cites W4243697740 @default.
• W2000604019 doi "https://doi.org/10.1021/cg100212q" @default.
• W2000604019 hasPublicationYear "2010" @default.
• W2000604019 type Work @default.
• W2000604019 sameAs 2000604019 @default.
• W2000604019 citedByCount "12" @default.
• W2000604019 countsByYear W20006040192012 @default.
• W2000604019 countsByYear W20006040192014 @default.
• W2000604019 countsByYear W20006040192016 @default.
• W2000604019 countsByYear W20006040192017 @default.
• W2000604019 countsByYear W20006040192018 @default.
• W2000604019 countsByYear W20006040192019 @default.
• W2000604019 countsByYear W20006040192023 @default.
• W2000604019 crossrefType "journal-article" @default.
• W2000604019 hasAuthorship W2000604019A5000506024 @default.
• W2000604019 hasAuthorship W2000604019A5020699395 @default.
• W2000604019 hasAuthorship W2000604019A5032291094 @default.
• W2000604019 hasAuthorship W2000604019A5035998519 @default.
• W2000604019 hasAuthorship W2000604019A5065540866 @default.
• W2000604019 hasAuthorship W2000604019A5091169774 @default.
• W2000604019 hasConcept C115624301 @default.
• W2000604019 hasConcept C120665830 @default.
• W2000604019 hasConcept C121332964 @default.
• W2000604019 hasConcept C147789679 @default.
• W2000604019 hasConcept C150394285 @default.
• W2000604019 hasConcept C165901193 @default.
• W2000604019 hasConcept C178790620 @default.
• W2000604019 hasConcept C185592680 @default.
• W2000604019 hasConcept C20976626 @default.
• W2000604019 hasConcept C2777411658 @default.
• W2000604019 hasConcept C2777629521 @default.
• W2000604019 hasConcept C32909587 @default.
• W2000604019 hasConcept C39519442 @default.
• W2000604019 hasConcept C40003534 @default.
• W2000604019 hasConcept C47542005 @default.
• W2000604019 hasConcept C54101563 @default.
• W2000604019 hasConcept C62520636 @default.
• W2000604019 hasConcept C8010536 @default.
• W2000604019 hasConcept C86803240 @default.
• W2000604019 hasConcept C90856448 @default.
• W2000604019 hasConcept C97355855 @default.
• W2000604019 hasConceptScore W2000604019C115624301 @default.
• W2000604019 hasConceptScore W2000604019C120665830 @default.
• W2000604019 hasConceptScore W2000604019C121332964 @default.
• W2000604019 hasConceptScore W2000604019C147789679 @default.
• W2000604019 hasConceptScore W2000604019C150394285 @default.
• W2000604019 hasConceptScore W2000604019C165901193 @default.
• W2000604019 hasConceptScore W2000604019C178790620 @default.
• W2000604019 hasConceptScore W2000604019C185592680 @default.
• W2000604019 hasConceptScore W2000604019C20976626 @default.
• W2000604019 hasConceptScore W2000604019C2777411658 @default.
• W2000604019 hasConceptScore W2000604019C2777629521 @default.
• W2000604019 hasConceptScore W2000604019C32909587 @default.
• W2000604019 hasConceptScore W2000604019C39519442 @default.
• W2000604019 hasConceptScore W2000604019C40003534 @default.
• W2000604019 hasConceptScore W2000604019C47542005 @default.
• W2000604019 hasConceptScore W2000604019C54101563 @default.
• W2000604019 hasConceptScore W2000604019C62520636 @default.
• W2000604019 hasConceptScore W2000604019C8010536 @default.
• W2000604019 hasConceptScore W2000604019C86803240 @default.
• W2000604019 hasConceptScore W2000604019C90856448 @default.
• W2000604019 hasConceptScore W2000604019C97355855 @default.
• W2000604019 hasIssue "7" @default.
• W2000604019 hasLocation W20006040191 @default.
• W2000604019 hasOpenAccess W2000604019 @default.
• W2000604019 hasPrimaryLocation W20006040191 @default.
• W2000604019 hasRelatedWork W15120608 @default.
• W2000604019 hasRelatedWork W2012345717 @default.
• W2000604019 hasRelatedWork W2012675768 @default.

• next