FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000604907> ?p ?o ?g. }

• W2000604907 endingPage "10" @default.
• W2000604907 startingPage "1" @default.
• W2000604907 abstract "Abstract Previously we showed that CHIP, a co-chaperone of Hsp70 and E3 ubiquitin ligase, can promote the degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis (fALS) via a mechanism not involving SOD1 ubiquitylation. Here we present evidence that CHIP functions in the interaction of mutant SOD1 with 26S proteasomes. Bag-1, a coupling factor between molecular chaperones and the proteasomes, formed a complex with SOD1 in an hsp70-dependent manner but had no direct effect on the degradation of mutant SOD1. Instead, Bag-1 stimulated interaction between CHIP and the proteasome-associated protein VCP (p97), which do not associate normally. Over-expressed CHIP interfered with the association between mutant SOD1 and VCP. Conversely, the binding of CHIP to mutant SOD1 was inhibited by VCP, implying that the chaperone complex and proteolytic machinery are competing for the common substrates. Finally we observed that mutant SOD1 strongly associated with the 19S complex of proteasomes and CHIP over-expression specifically reduced the interaction between S6/S6′ ATPase subunits and mutant SOD1. These results suggest that CHIP, together with ubiquitin-binding proteins such as Bag-1 and VCP, promotes the degradation of mutant SOD1 by facilitating its translocation from ATPase subunits of 19S complex to the 20S core particle." @default.
• W2000604907 created "2016-06-24" @default.
• W2000604907 creator A5069349165 @default.
• W2000604907 creator A5073203649 @default.
• W2000604907 date "2010-03-01" @default.
• W2000604907 modified "2023-09-26" @default.
• W2000604907 title "CHIP promotes the degradation of mutant SOD1 by reducing its interaction with VCP and S6/S6′ subunits of 26S proteasome" @default.
• W2000604907 cites W1528623936 @default.
• W2000604907 cites W1583282648 @default.
• W2000604907 cites W1971841367 @default.
• W2000604907 cites W1976787386 @default.
• W2000604907 cites W1978922366 @default.
• W2000604907 cites W1983982920 @default.
• W2000604907 cites W1984136850 @default.
• W2000604907 cites W1984741367 @default.
• W2000604907 cites W1986111043 @default.
• W2000604907 cites W1986906983 @default.
• W2000604907 cites W1999001130 @default.
• W2000604907 cites W2000409052 @default.
• W2000604907 cites W2014497390 @default.
• W2000604907 cites W2018462246 @default.
• W2000604907 cites W2021242983 @default.
• W2000604907 cites W2023053159 @default.
• W2000604907 cites W2025497897 @default.
• W2000604907 cites W2037558767 @default.
• W2000604907 cites W2037913550 @default.
• W2000604907 cites W2040833814 @default.
• W2000604907 cites W2081103757 @default.
• W2000604907 cites W2083081815 @default.
• W2000604907 cites W2110780830 @default.
• W2000604907 cites W2116598203 @default.
• W2000604907 cites W2120717592 @default.
• W2000604907 cites W2120947942 @default.
• W2000604907 cites W2125774668 @default.
• W2000604907 cites W2141424523 @default.
• W2000604907 cites W2157295566 @default.
• W2000604907 doi "https://doi.org/10.1080/19768351003765145" @default.
• W2000604907 hasPublicationYear "2010" @default.
• W2000604907 type Work @default.
• W2000604907 sameAs 2000604907 @default.
• W2000604907 citedByCount "11" @default.
• W2000604907 countsByYear W20006049072012 @default.
• W2000604907 countsByYear W20006049072013 @default.
• W2000604907 countsByYear W20006049072015 @default.
• W2000604907 countsByYear W20006049072016 @default.
• W2000604907 countsByYear W20006049072019 @default.
• W2000604907 countsByYear W20006049072020 @default.
• W2000604907 countsByYear W20006049072021 @default.
• W2000604907 countsByYear W20006049072023 @default.
• W2000604907 crossrefType "journal-article" @default.
• W2000604907 hasAuthorship W2000604907A5069349165 @default.
• W2000604907 hasAuthorship W2000604907A5073203649 @default.
• W2000604907 hasBestOaLocation W20006049071 @default.
• W2000604907 hasConcept C104317684 @default.
• W2000604907 hasConcept C134459356 @default.
• W2000604907 hasConcept C142724271 @default.
• W2000604907 hasConcept C143065580 @default.
• W2000604907 hasConcept C181199279 @default.
• W2000604907 hasConcept C185592680 @default.
• W2000604907 hasConcept C205260736 @default.
• W2000604907 hasConcept C23265538 @default.
• W2000604907 hasConcept C25602115 @default.
• W2000604907 hasConcept C27740335 @default.
• W2000604907 hasConcept C2775962898 @default.
• W2000604907 hasConcept C2777615887 @default.
• W2000604907 hasConcept C2992195973 @default.
• W2000604907 hasConcept C55493867 @default.
• W2000604907 hasConcept C68991219 @default.
• W2000604907 hasConcept C71924100 @default.
• W2000604907 hasConcept C86803240 @default.
• W2000604907 hasConcept C95444343 @default.
• W2000604907 hasConceptScore W2000604907C104317684 @default.
• W2000604907 hasConceptScore W2000604907C134459356 @default.
• W2000604907 hasConceptScore W2000604907C142724271 @default.
• W2000604907 hasConceptScore W2000604907C143065580 @default.
• W2000604907 hasConceptScore W2000604907C181199279 @default.
• W2000604907 hasConceptScore W2000604907C185592680 @default.
• W2000604907 hasConceptScore W2000604907C205260736 @default.
• W2000604907 hasConceptScore W2000604907C23265538 @default.
• W2000604907 hasConceptScore W2000604907C25602115 @default.
• W2000604907 hasConceptScore W2000604907C27740335 @default.
• W2000604907 hasConceptScore W2000604907C2775962898 @default.
• W2000604907 hasConceptScore W2000604907C2777615887 @default.
• W2000604907 hasConceptScore W2000604907C2992195973 @default.
• W2000604907 hasConceptScore W2000604907C55493867 @default.
• W2000604907 hasConceptScore W2000604907C68991219 @default.
• W2000604907 hasConceptScore W2000604907C71924100 @default.
• W2000604907 hasConceptScore W2000604907C86803240 @default.
• W2000604907 hasConceptScore W2000604907C95444343 @default.
• W2000604907 hasIssue "1" @default.
• W2000604907 hasLocation W20006049071 @default.
• W2000604907 hasOpenAccess W2000604907 @default.
• W2000604907 hasPrimaryLocation W20006049071 @default.
• W2000604907 hasRelatedWork W1505406152 @default.
• W2000604907 hasRelatedWork W1990976985 @default.
• W2000604907 hasRelatedWork W2000604907 @default.
• W2000604907 hasRelatedWork W2014497390 @default.
• W2000604907 hasRelatedWork W2019341167 @default.

• next