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• W2000605108 abstract "Abstract The effects of curcumin on cell proliferation, activation-induced cell death (AICD) and expression of interleukin-2 (IL-2) receptors (IL-2Rα, CD25) by Jurkat cells were investigated. Incubation of Jurkat cells for 72 h with either phytohaemagglutinin (PHA) or curcumin (2.5 μg/mL) resulted in marked inhibition of cell proliferation, determined by 3 H-thymidine incorporation. The anticancer activity of curcumin was also confirmed by quantitating the PHA-induced AICD in Jurkat cells by flow cytometry. It was found that curcumin (2.5 μg/mL) enhanced apoptosis in PHA-treated Jurkat cells. Further we observed the level of CD25 expression on Jurkat cells by flow cytometry. Our data indicate that curcumin inhibited PHA-induced CD25 expression. The present study suggests that curcumin have potent anticancer activities, which might be useful in lymphoma treatment." @default.
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• W2000605108 date "2011-01-01" @default.
• W2000605108 modified "2023-09-26" @default.
• W2000605108 title "Curcumin inhibits Jurkat cell proliferation by inducing apoptosis via activation-induced cell death" @default.
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• W2000605108 doi "https://doi.org/10.1016/j.bionut.2011.02.001" @default.
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