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- W2000606463 abstract "To the Editor: The review of vitamin E supplementation for prevention of coronary heart disease by Pruthi et al1Pruthi S Allison TG Hensrud DD Vitamin E supplementation in the prevention of coronary heart disease.Mayo Clin Proc. 2001; 76: 1131-1136Abstract Full Text Full Text PDF PubMed Scopus (52) Google Scholar neglected an important study. The Secondary Prevention With Antioxidants of Cardiovascular Disease in Endstage Renal Disease (SPACE) trial showed a statistically and clinically significant benefit of vitamin E supplementation for secondary prevention of myocardial infarction in patients receiving hemodialysis.2Boaz M Smetana S Weinstein T et al.Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial.Lancet. 2000; 356: 1213-1218Abstract Full Text Full Text PDF PubMed Scopus (934) Google Scholar The discrepancy between these results and those of other trials discussed in their review may be due to the high dose of vitamin E used (800 IU/d), as well as the SPACE cohort's high incidence of events and the relatively greater role oxidative stress may play in atherogenesis in patients receiving dialysis. Vitamin E Use in Preventing Coronary Heart Disease in Patients Undergoing Dialysis: In ResponseMayo Clinic ProceedingsVol. 77Issue 3PreviewWe agree with Dr Rein that vitamin E appeared to benefit patients receiving hemodialysis in the SPACE study, which used a primary end point of combined nonfatal and fatal myocardial infarction, ischemic stroke, peripheral vascular disease, and unstable angina. If this study is replicated, vitamin E may provide an important adjunctive treatment in this high-risk group. Our review focused on the effect of vitamin E in the primary and secondary prevention of coronary heart disease (CHD) in the general population. Full-Text PDF" @default.
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- W2000606463 date "2002-03-01" @default.
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- W2000606463 title "Vitamin E Use in Preventing Coronary Heart Disease in Patients Undergoing Dialysis" @default.
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