FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000607553> ?p ?o ?g. }

• W2000607553 endingPage "525" @default.
• W2000607553 startingPage "518" @default.
• W2000607553 abstract "BACKGROUND: Complete pathological response has proven prognostic benefits in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Sequential 18-FDG PET may be an early surrogate for pathological response to chemoradiotherapy. OBJECTIVES: The aim of this study was to identify whether metabolic response measured by FDG PET following chemoradiotherapy is prognostic for tumor recurrence and survival following neoadjuvant therapy and surgical treatment for primary rectal cancer. METHODS: Patients with primary rectal cancer treated by long-course neoadjuvant chemoradiotherapy followed by surgery had FDG PET performed before and 4 weeks after treatment, before surgical resection was performed. Retrospective chart review was undertaken for patient demographics, tumor staging, recurrence rates, and survival. RESULTS: Between 2000 and 2007, 78 patients were identified (53 male, 25 female; median age, 64 y). After chemoradiotherapy, 37 patients (47%) had a complete metabolic response, 26 (33%) had a partial metabolic response, and 14 (18%) had no metabolic response as assessed by FDG PET (1 patient had missing data). However, only 4 patients (5%) had a complete pathological response. The median postoperative follow-up period was 3.1 years during which 14 patients (19%) had a recurrence: 2 local, 9 distant, and 3 with both local and distant. The estimated percentage without recurrence was 77% at 5 years (95% CI 66%–89%). There was an inverse relationship between FDG PET metabolic response and the incidence of recurrence within 3 years (P = .04). Kaplan-Meier analysis of FDG PET metabolic response and overall survival demonstrated a significant difference in survival among patients in the 3 arms: complete, partial, and no metabolic response (P = .04); the patients with complete metabolic response had the best prognosis. CONCLUSION: Complete or partial metabolic response on PET following neoadjuvant chemoradiotherapy and surgery predicts a lower local recurrence rate and improved survival compared with patients with no metabolic response. Metabolic response may be used to stratify prognosis in patients with rectal cancer." @default.
• W2000607553 created "2016-06-24" @default.
• W2000607553 creator A5001910534 @default.
• W2000607553 creator A5010510721 @default.
• W2000607553 creator A5023128779 @default.
• W2000607553 creator A5025712174 @default.
• W2000607553 creator A5060586557 @default.
• W2000607553 creator A5074354371 @default.
• W2000607553 creator A5079422749 @default.
• W2000607553 creator A5082497051 @default.
• W2000607553 creator A5084869285 @default.
• W2000607553 creator A5087627680 @default.
• W2000607553 date "2011-05-01" @default.
• W2000607553 modified "2023-09-26" @default.
• W2000607553 title "Metabolic Response of Rectal Cancer Assessed by 18-FDG PET Following Chemoradiotherapy is Prognostic for Patient Outcome" @default.
• W2000607553 cites W1964532421 @default.
• W2000607553 cites W1967570288 @default.
• W2000607553 cites W1973101195 @default.
• W2000607553 cites W1984520119 @default.
• W2000607553 cites W1991109178 @default.
• W2000607553 cites W2003308262 @default.
• W2000607553 cites W2006236645 @default.
• W2000607553 cites W2010418249 @default.
• W2000607553 cites W2013835366 @default.
• W2000607553 cites W2014355159 @default.
• W2000607553 cites W2019588032 @default.
• W2000607553 cites W2019607817 @default.
• W2000607553 cites W2019696059 @default.
• W2000607553 cites W2021463818 @default.
• W2000607553 cites W2022617644 @default.
• W2000607553 cites W2024638834 @default.
• W2000607553 cites W2034887943 @default.
• W2000607553 cites W2039494288 @default.
• W2000607553 cites W2057903664 @default.
• W2000607553 cites W2058054443 @default.
• W2000607553 cites W2069812911 @default.
• W2000607553 cites W2074349113 @default.
• W2000607553 cites W2077402958 @default.
• W2000607553 cites W2077556181 @default.
• W2000607553 cites W2078780440 @default.
• W2000607553 cites W2084330270 @default.
• W2000607553 cites W2089008773 @default.
• W2000607553 cites W2109509934 @default.
• W2000607553 cites W2122374760 @default.
• W2000607553 cites W2124297369 @default.
• W2000607553 cites W2124468792 @default.
• W2000607553 cites W2152237301 @default.
• W2000607553 cites W2066099729 @default.
• W2000607553 doi "https://doi.org/10.1007/dcr.0b013e31820b36f0" @default.
• W2000607553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21471751" @default.
• W2000607553 hasPublicationYear "2011" @default.
• W2000607553 type Work @default.
• W2000607553 sameAs 2000607553 @default.
• W2000607553 citedByCount "28" @default.
• W2000607553 countsByYear W20006075532012 @default.
• W2000607553 countsByYear W20006075532013 @default.
• W2000607553 countsByYear W20006075532014 @default.
• W2000607553 countsByYear W20006075532015 @default.
• W2000607553 countsByYear W20006075532016 @default.
• W2000607553 countsByYear W20006075532018 @default.
• W2000607553 countsByYear W20006075532020 @default.
• W2000607553 countsByYear W20006075532022 @default.
• W2000607553 crossrefType "journal-article" @default.
• W2000607553 hasAuthorship W2000607553A5001910534 @default.
• W2000607553 hasAuthorship W2000607553A5010510721 @default.
• W2000607553 hasAuthorship W2000607553A5023128779 @default.
• W2000607553 hasAuthorship W2000607553A5025712174 @default.
• W2000607553 hasAuthorship W2000607553A5060586557 @default.
• W2000607553 hasAuthorship W2000607553A5074354371 @default.
• W2000607553 hasAuthorship W2000607553A5079422749 @default.
• W2000607553 hasAuthorship W2000607553A5082497051 @default.
• W2000607553 hasAuthorship W2000607553A5084869285 @default.
• W2000607553 hasAuthorship W2000607553A5087627680 @default.
• W2000607553 hasConcept C121608353 @default.
• W2000607553 hasConcept C126322002 @default.
• W2000607553 hasConcept C126838900 @default.
• W2000607553 hasConcept C141071460 @default.
• W2000607553 hasConcept C143998085 @default.
• W2000607553 hasConcept C167135981 @default.
• W2000607553 hasConcept C207886595 @default.
• W2000607553 hasConcept C2778292576 @default.
• W2000607553 hasConcept C2778424827 @default.
• W2000607553 hasConcept C526805850 @default.
• W2000607553 hasConcept C530470458 @default.
• W2000607553 hasConcept C71924100 @default.
• W2000607553 hasConceptScore W2000607553C121608353 @default.
• W2000607553 hasConceptScore W2000607553C126322002 @default.
• W2000607553 hasConceptScore W2000607553C126838900 @default.
• W2000607553 hasConceptScore W2000607553C141071460 @default.
• W2000607553 hasConceptScore W2000607553C143998085 @default.
• W2000607553 hasConceptScore W2000607553C167135981 @default.
• W2000607553 hasConceptScore W2000607553C207886595 @default.
• W2000607553 hasConceptScore W2000607553C2778292576 @default.
• W2000607553 hasConceptScore W2000607553C2778424827 @default.
• W2000607553 hasConceptScore W2000607553C526805850 @default.
• W2000607553 hasConceptScore W2000607553C530470458 @default.
• W2000607553 hasConceptScore W2000607553C71924100 @default.
• W2000607553 hasIssue "5" @default.

• next