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- W2000609341 abstract "The effects of α-adrenergic and serotonergic receptor agonist administration on spinal analgesia mechanisms (D'Amour-Smith analgesia assay) were examined in the spinal rat from 6 h to 3 weeks following transection. Analgesia (increased response latency)_was observed following administration of the α-adrenergic agonists, clonidine or xylazine at all times after transection. This dose-response-related analgesia was blocked by pretreatment with the α-adrenergic receptor blocker phenoxybenzamine but not by the serotonergic receptor blocker metergoline. Biochemical asay of spinal cord noradrenaline (NA) caudal to the level of transection indicated that the above drugs were effective agonists even when NA levels were not detectable suggesting a mechanism of action via direct Receptor stimulation. Administration of the serotonergic receptor stimulants quipazine or 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) was analgesic only during the first few postoperative days. Specificity of these drugs for the serotonergic receptor is supported by the observations that the drug induced analgesia was blocked by pretreatment with metergoline but not by phenoxybenzamine and that while quipazine or 5-MeODMT administration was only analgesic immediately following transection, α-adrenergic agonists were effective at all times. The implications of the present data for the involvement of descending NA and serotonergic fiber systems in the mediation of narcotic analgesia is discussed. The present data suggest that C.N.S. active α-adrenergic agonists may represent a class of non-narcotic analgesics of future clinical importance." @default.
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- W2000609341 title "Noradrenergic and serotonergic mediation of spinal analgesia mechanisms" @default.
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- W2000609341 doi "https://doi.org/10.1016/0014-2999(80)90154-5" @default.
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