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• W2000609514 endingPage "e43128" @default.
• W2000609514 startingPage "e43128" @default.
• W2000609514 abstract "Recent research supports the view that changes in gene regulation, as opposed to changes in the genes themselves, play a significant role in morphological evolution. Gene regulation is largely dependent on transcription factor binding sites. Researchers are now able to use the available 29 mammalian genomes to measure selective constraint at the level of binding sites. This detailed map of constraint suggests that mammalian genomes co-opt fragments of mobile elements to act as gene regulatory sequence on a large scale. In the human genome we detect over 280,000 putative regulatory elements, totaling approximately 7 Mb of sequence, that originated as mobile element insertions. These putative regulatory regions are conserved non-exonic elements (CNEEs), which show considerable cross-species constraint and signatures of continued negative selection in humans, yet do not appear in a known mature transcript. These putative regulatory elements were co-opted from SINE, LINE, LTR and DNA transposon insertions. We demonstrate that at least 11%, and an estimated 20%, of gene regulatory sequence in the human genome showing cross-species conservation was co-opted from mobile elements. The location in the genome of CNEEs co-opted from mobile elements closely resembles that of CNEEs in general, except in the centers of the largest gene deserts where recognizable co-option events are relatively rare. We find that regions of certain mobile element insertions are more likely to be held under purifying selection than others. In particular, we show 6 examples where paralogous instances of an often co-opted mobile element region define a sequence motif that closely matches a transcription factor’s binding profile." @default.
• W2000609514 created "2016-06-24" @default.
• W2000609514 creator A5088243805 @default.
• W2000609514 creator A5090849321 @default.
• W2000609514 date "2012-08-27" @default.
• W2000609514 modified "2023-10-15" @default.
• W2000609514 title "29 Mammalian Genomes Reveal Novel Exaptations of Mobile Elements for Likely Regulatory Functions in the Human Genome" @default.
• W2000609514 cites W1491989688 @default.
• W2000609514 cites W1592870802 @default.
• W2000609514 cites W1594381616 @default.
• W2000609514 cites W189143987 @default.
• W2000609514 cites W1968189089 @default.
• W2000609514 cites W1980121867 @default.
• W2000609514 cites W1985738984 @default.
• W2000609514 cites W1989728485 @default.
• W2000609514 cites W1992993799 @default.
• W2000609514 cites W1994791166 @default.
• W2000609514 cites W1996601092 @default.
• W2000609514 cites W1997944100 @default.
• W2000609514 cites W2011457803 @default.
• W2000609514 cites W2012036024 @default.
• W2000609514 cites W2021434409 @default.
• W2000609514 cites W2024439539 @default.
• W2000609514 cites W2028548770 @default.
• W2000609514 cites W2029722028 @default.
• W2000609514 cites W2031750380 @default.
• W2000609514 cites W2033049603 @default.
• W2000609514 cites W2036370616 @default.
• W2000609514 cites W2038812033 @default.
• W2000609514 cites W2039011562 @default.
• W2000609514 cites W2042086471 @default.
• W2000609514 cites W2048263136 @default.
• W2000609514 cites W2048385877 @default.
• W2000609514 cites W2055143633 @default.
• W2000609514 cites W2057587811 @default.
• W2000609514 cites W2057829817 @default.
• W2000609514 cites W2060392690 @default.
• W2000609514 cites W2062478949 @default.
• W2000609514 cites W2063007091 @default.
• W2000609514 cites W2063669037 @default.
• W2000609514 cites W2071501400 @default.
• W2000609514 cites W2075739994 @default.
• W2000609514 cites W2079671119 @default.
• W2000609514 cites W2083653513 @default.
• W2000609514 cites W2084694423 @default.
• W2000609514 cites W2085024301 @default.
• W2000609514 cites W2087700126 @default.
• W2000609514 cites W2090390027 @default.
• W2000609514 cites W2091656649 @default.
• W2000609514 cites W2091851394 @default.
• W2000609514 cites W2094913043 @default.
• W2000609514 cites W2095595375 @default.
• W2000609514 cites W2098941203 @default.
• W2000609514 cites W2100990361 @default.
• W2000609514 cites W2101735289 @default.
• W2000609514 cites W2102304447 @default.
• W2000609514 cites W2103777723 @default.
• W2000609514 cites W2104905992 @default.
• W2000609514 cites W2106533942 @default.
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• W2000609514 cites W2117904145 @default.
• W2000609514 cites W2122977880 @default.
• W2000609514 cites W2123728510 @default.
• W2000609514 cites W2128969076 @default.
• W2000609514 cites W2129016996 @default.
• W2000609514 cites W2131581981 @default.
• W2000609514 cites W2134913157 @default.
• W2000609514 cites W2135030836 @default.
• W2000609514 cites W2136606329 @default.
• W2000609514 cites W2142204199 @default.
• W2000609514 cites W2144882930 @default.
• W2000609514 cites W2145191876 @default.
• W2000609514 cites W2146640191 @default.
• W2000609514 cites W2147449602 @default.
• W2000609514 cites W2150733663 @default.
• W2000609514 cites W2151464048 @default.
• W2000609514 cites W2151744930 @default.
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• W2000609514 cites W2164207497 @default.
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• W2000609514 doi "https://doi.org/10.1371/journal.pone.0043128" @default.
• W2000609514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3428314" @default.
• W2000609514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22952639" @default.
• W2000609514 hasPublicationYear "2012" @default.
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