FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000610364> ?p ?o ?g. }

• W2000610364 endingPage "F917" @default.
• W2000610364 startingPage "F908" @default.
• W2000610364 abstract "High NaCl activates the transcription factor nuclear factor of activated T cells 5 (NFAT5), leading to increased transcription of osmoprotective target genes. Kinases PKA, PI3K, AKT1, and p38α were known to contribute to the high NaCl-induced increase of NFAT5 activity. We now identify another kinase, GSK-3β. siRNA-mediated knock-down of GSK-3β increases NFAT5 transcriptional and transactivating activities without affecting high NaCl-induced nuclear localization of NFAT5 or NFAT5 protein expression. High NaCl increases phosphorylation of GSK-3β-S9, which inhibits GSK-3β. In GSK-3β-null mouse embryonic fibroblasts transfection of GSK-3β, in which serine 9 is mutated to alanine, so that it cannot be inhibited by phosphorylation at that site, inhibits high NaCl-induced NFAT5 transcriptional activity more than transfection of wild-type GSK-3β. High NaCl-induced phosphorylation of GSK-3β-S9 depends on PKA, PI3K, and AKT, but not p38α. Overexpression of PKA catalytic subunit α or of catalytically active AKT1 reduces inhibition of NFAT5 by GSK-3β, but overexpression of p38α together with its catalytically active upstream kinase, MKK6, does not. Thus, GSK-3β normally inhibits NFAT5 by suppressing its transactivating activity. When activated by high NaCl, PKA, PI3K, and AKT1, but not p38α, increase phosphorylation of GSK-3β-S9, which reduces the inhibitory effect of GSK-3β on NFAT5, and thus contributes to activation of NFAT5." @default.
• W2000610364 created "2016-06-24" @default.
• W2000610364 creator A5025916093 @default.
• W2000610364 creator A5033020983 @default.
• W2000610364 creator A5051074151 @default.
• W2000610364 creator A5070372136 @default.
• W2000610364 date "2013-04-01" @default.
• W2000610364 modified "2023-09-23" @default.
• W2000610364 title "Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP)" @default.
• W2000610364 cites W1555947589 @default.
• W2000610364 cites W1601657500 @default.
• W2000610364 cites W1963561816 @default.
• W2000610364 cites W1964367654 @default.
• W2000610364 cites W1964379721 @default.
• W2000610364 cites W1968946701 @default.
• W2000610364 cites W1972343960 @default.
• W2000610364 cites W1972762681 @default.
• W2000610364 cites W1979560455 @default.
• W2000610364 cites W1983001423 @default.
• W2000610364 cites W1983611255 @default.
• W2000610364 cites W1991845983 @default.
• W2000610364 cites W1996888339 @default.
• W2000610364 cites W2006470470 @default.
• W2000610364 cites W2010723117 @default.
• W2000610364 cites W2012266404 @default.
• W2000610364 cites W2016497346 @default.
• W2000610364 cites W2018328223 @default.
• W2000610364 cites W2019968039 @default.
• W2000610364 cites W2021532100 @default.
• W2000610364 cites W2023578861 @default.
• W2000610364 cites W2025293338 @default.
• W2000610364 cites W2025699489 @default.
• W2000610364 cites W2027148985 @default.
• W2000610364 cites W2027420168 @default.
• W2000610364 cites W2027942573 @default.
• W2000610364 cites W2029643611 @default.
• W2000610364 cites W2034467929 @default.
• W2000610364 cites W2038073573 @default.
• W2000610364 cites W2038084705 @default.
• W2000610364 cites W2039842713 @default.
• W2000610364 cites W2040932519 @default.
• W2000610364 cites W2041113521 @default.
• W2000610364 cites W2042730534 @default.
• W2000610364 cites W2046033677 @default.
• W2000610364 cites W2048639483 @default.
• W2000610364 cites W2054670584 @default.
• W2000610364 cites W2056907950 @default.
• W2000610364 cites W2063652987 @default.
• W2000610364 cites W2064979841 @default.
• W2000610364 cites W2067801310 @default.
• W2000610364 cites W2070875167 @default.
• W2000610364 cites W2070942270 @default.
• W2000610364 cites W2073265912 @default.
• W2000610364 cites W2074475161 @default.
• W2000610364 cites W2074883812 @default.
• W2000610364 cites W2076892771 @default.
• W2000610364 cites W2076999277 @default.
• W2000610364 cites W2080111163 @default.
• W2000610364 cites W2084500594 @default.
• W2000610364 cites W2087092876 @default.
• W2000610364 cites W2090444383 @default.
• W2000610364 cites W2091373459 @default.
• W2000610364 cites W2092879837 @default.
• W2000610364 cites W2104987037 @default.
• W2000610364 cites W2109346042 @default.
• W2000610364 cites W2129713711 @default.
• W2000610364 cites W2130843143 @default.
• W2000610364 cites W2138625970 @default.
• W2000610364 cites W2140725550 @default.
• W2000610364 cites W2142297099 @default.
• W2000610364 cites W2142493853 @default.
• W2000610364 cites W2145958552 @default.
• W2000610364 cites W2147678437 @default.
• W2000610364 cites W2148736421 @default.
• W2000610364 cites W2152265294 @default.
• W2000610364 cites W2167028704 @default.
• W2000610364 cites W2167413184 @default.
• W2000610364 cites W2169722304 @default.
• W2000610364 cites W2184829069 @default.
• W2000610364 cites W2337213344 @default.
• W2000610364 cites W93095250 @default.
• W2000610364 doi "https://doi.org/10.1152/ajprenal.00591.2012" @default.
• W2000610364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3625851" @default.
• W2000610364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23324178" @default.
• W2000610364 hasPublicationYear "2013" @default.
• W2000610364 type Work @default.
• W2000610364 sameAs 2000610364 @default.
• W2000610364 citedByCount "32" @default.
• W2000610364 countsByYear W20006103642013 @default.
• W2000610364 countsByYear W20006103642014 @default.
• W2000610364 countsByYear W20006103642015 @default.
• W2000610364 countsByYear W20006103642016 @default.
• W2000610364 countsByYear W20006103642017 @default.
• W2000610364 countsByYear W20006103642018 @default.
• W2000610364 countsByYear W20006103642019 @default.
• W2000610364 countsByYear W20006103642020 @default.
• W2000610364 countsByYear W20006103642021 @default.
• W2000610364 countsByYear W20006103642022 @default.

• next