FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000610689> ?p ?o ?g. }

• W2000610689 endingPage "542" @default.
• W2000610689 startingPage "530" @default.
• W2000610689 abstract "Adenosine produces cardiovascular depressor effects in various brain regions. However, the cellular mechanisms underlying these effects remain unclear. The pre-sympathetic neurons in the hypothalamic paraventricular nucleus (PVN) play an important role in regulating arterial blood pressure and sympathetic outflow through projections to the spinal cord and brainstem. In this study, we performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the intermediolateral cell column of the spinal cord in rats. Adenosine (10-100 microM) decreased the firing activity in a concentration-dependent manner, with a marked hyperpolarization in 12 of 26 neurons tested. Blockade of A(1) receptors with the adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or intracellular dialysis of guanosine 5'-O-(2-thodiphosphate) eliminated the inhibitory effect of adenosine on labeled PVN neurons. Immunocytochemical labeling revealed that A(1) receptors were expressed on spinally projecting PVN neurons. Also, blocking ATP-dependent K(+) (K(ATP)) channels with 100 microM glibenclamide or 200 microM tolbutamide, but not the G protein-coupled inwardly rectifying K(+) channels blocker tertiapin-Q, abolished the inhibitory effect of adenosine on the firing activity of PVN neurons. Furthermore, glibenclamide or tolbutamide significantly decreased the adenosine-induced outward currents in labeled neurons. The reversal potential of adenosine-induced currents was close to the K(+) equilibrium potential. In addition, adenosine decreased the frequency of both spontaneous and miniature glutamatergic excitatory post-synaptic currents and GABAergic inhibitory post-synaptic currents in labeled neurons, and these effects were also blocked by 8-cyclopentyl-1,3-dipropylxanthine. Collectively, our findings suggest that adenosine inhibits the excitability of PVN pre-sympathetic neurons through A(1) receptor-mediated opening of K(ATP) channels." @default.
• W2000610689 created "2016-06-24" @default.
• W2000610689 creator A5002812144 @default.
• W2000610689 creator A5035159001 @default.
• W2000610689 creator A5085520556 @default.
• W2000610689 date "2010-04-01" @default.
• W2000610689 modified "2023-09-23" @default.
• W2000610689 title "Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels" @default.
• W2000610689 cites W1551550807 @default.
• W2000610689 cites W1570053755 @default.
• W2000610689 cites W1571545340 @default.
• W2000610689 cites W1963692643 @default.
• W2000610689 cites W1974864403 @default.
• W2000610689 cites W1980302631 @default.
• W2000610689 cites W1985341212 @default.
• W2000610689 cites W1994217011 @default.
• W2000610689 cites W2000065539 @default.
• W2000610689 cites W2006293323 @default.
• W2000610689 cites W2011638127 @default.
• W2000610689 cites W2014580405 @default.
• W2000610689 cites W2018654901 @default.
• W2000610689 cites W2023217927 @default.
• W2000610689 cites W2032551220 @default.
• W2000610689 cites W2037848467 @default.
• W2000610689 cites W2039055923 @default.
• W2000610689 cites W2044074327 @default.
• W2000610689 cites W2046138799 @default.
• W2000610689 cites W2050252994 @default.
• W2000610689 cites W2050889708 @default.
• W2000610689 cites W2054410946 @default.
• W2000610689 cites W2066479748 @default.
• W2000610689 cites W2066650398 @default.
• W2000610689 cites W2074146366 @default.
• W2000610689 cites W2080170127 @default.
• W2000610689 cites W2080322849 @default.
• W2000610689 cites W2080875376 @default.
• W2000610689 cites W2083337747 @default.
• W2000610689 cites W2087487440 @default.
• W2000610689 cites W2087881873 @default.
• W2000610689 cites W2089036949 @default.
• W2000610689 cites W2097550685 @default.
• W2000610689 cites W2104355402 @default.
• W2000610689 cites W2109314119 @default.
• W2000610689 cites W2109776154 @default.
• W2000610689 cites W2111646184 @default.
• W2000610689 cites W2111841009 @default.
• W2000610689 cites W2116819517 @default.
• W2000610689 cites W2117789967 @default.
• W2000610689 cites W2123176668 @default.
• W2000610689 cites W2126155748 @default.
• W2000610689 cites W2129340317 @default.
• W2000610689 cites W2130736859 @default.
• W2000610689 cites W2137171780 @default.
• W2000610689 cites W2145758516 @default.
• W2000610689 cites W2150728457 @default.
• W2000610689 cites W2159767473 @default.
• W2000610689 cites W2160262187 @default.
• W2000610689 cites W2162213293 @default.
• W2000610689 cites W2168840998 @default.
• W2000610689 cites W2398881773 @default.
• W2000610689 cites W2503359891 @default.
• W2000610689 cites W4232504825 @default.
• W2000610689 cites W4248350370 @default.
• W2000610689 doi "https://doi.org/10.1111/j.1471-4159.2010.06618.x" @default.
• W2000610689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20096091" @default.
• W2000610689 hasPublicationYear "2010" @default.
• W2000610689 type Work @default.
• W2000610689 sameAs 2000610689 @default.
• W2000610689 citedByCount "28" @default.
• W2000610689 countsByYear W20006106892012 @default.
• W2000610689 countsByYear W20006106892013 @default.
• W2000610689 countsByYear W20006106892014 @default.
• W2000610689 countsByYear W20006106892015 @default.
• W2000610689 countsByYear W20006106892016 @default.
• W2000610689 countsByYear W20006106892017 @default.
• W2000610689 countsByYear W20006106892018 @default.
• W2000610689 countsByYear W20006106892019 @default.
• W2000610689 countsByYear W20006106892020 @default.
• W2000610689 countsByYear W20006106892022 @default.
• W2000610689 countsByYear W20006106892023 @default.
• W2000610689 crossrefType "journal-article" @default.
• W2000610689 hasAuthorship W2000610689A5002812144 @default.
• W2000610689 hasAuthorship W2000610689A5035159001 @default.
• W2000610689 hasAuthorship W2000610689A5085520556 @default.
• W2000610689 hasConcept C112592302 @default.
• W2000610689 hasConcept C126322002 @default.
• W2000610689 hasConcept C131453863 @default.
• W2000610689 hasConcept C134018914 @default.
• W2000610689 hasConcept C169760540 @default.
• W2000610689 hasConcept C170493617 @default.
• W2000610689 hasConcept C17077164 @default.
• W2000610689 hasConcept C178790620 @default.
• W2000610689 hasConcept C182683403 @default.
• W2000610689 hasConcept C185592680 @default.
• W2000610689 hasConcept C2776991684 @default.
• W2000610689 hasConcept C2778938600 @default.
• W2000610689 hasConcept C66974803 @default.
• W2000610689 hasConcept C67907053 @default.

• next