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- W2000610770 abstract "Dyphylline is a methylxanthine bronchodilator with such a short a biologic t½ that development of practical dosing regimens has been difficult. Because its rapid renal elimination suggests active secretion, the effect of 1 gm probenecid on single-dose elimination kinetics of dyphylline was determined. Twelve subjects (six male, six female) participated in a crossover design. Subjects were their own controls and received dyphylline, 20 mg/kg orally, alone and after probenecid. The dyphylline t½ increased from 2.57 ± 0.45 to 4.88 ± 1.2 hr, whereas the elimination rate constant decreased from 0.276 ± 0.056 to 0.150 ± 0.037 hr−1 after probenecid. There was no significant change in the dyphylline apparent volume of distribution. Dyphylline total body clearance fell from 173 ± 20 to 95 ± 12 ml/kg · hr. The combined use of these drugs may lead to a practical dyphylline dosage schedule in aminophylline-hypersensitive patients or those incapacitated by theophylline gastrointestinal side effects. Clinical Pharmacology and Therapeutics (1983) 33, 822–825; doi:10.1038/clpt.1983.112" @default.
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- W2000610770 date "1983-06-01" @default.
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- W2000610770 title "Effect of probenecid on dyphylline elimination" @default.
- W2000610770 doi "https://doi.org/10.1038/clpt.1983.112" @default.
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