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- W2000610936 abstract "Alzheimer's disease (AD) is a progressive degenerative brain disorder that is characterized by neuronal loss, neurofibrillary tangles, and the abnormal deposition of senile plaque and amyloid β peptide (Aβ). The brains of AD patients are under intense oxidative stress. The overproduction of Aβ leads to Aβ-associated free radical oxidative stress. In this study, the antioxidative and neuronal protective effects of Punica granatum extract were investigated against oxidative stress-induced cytotoxicity in PC12 cells. The ethanol extracts of P. granatum protected PC12 cells from hydrogen peroxide (H2O2)-induced oxidative stress. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assays revealed a significant increase in cell viability when oxidatively stressed PC12 cells were treated with the P. granatum extract. To examine the effects of P. granatum on Aβ1–42-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Treatment with the extract of P. granatum increased step-through latency in mice injected with Aβ1–42. The results of this study suggest that the ethanol extract of P. granatum mitigated H2O2-induced oxidative stress in PC12 cells. In addition, the extract inhibited neuronal cell death caused by Aβ-induced oxidative stress and Aβ-induced learning and memory deficiency." @default.
- W2000610936 created "2016-06-24" @default.
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- W2000610936 date "2011-07-01" @default.
- W2000610936 modified "2023-10-18" @default.
- W2000610936 title "<i>Punica granatum</i> Protects Against Oxidative Stress in PC12 Cells and Oxidative Stress-Induced Alzheimer's Symptoms in Mice" @default.
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- W2000610936 doi "https://doi.org/10.1089/jmf.2010.1452" @default.
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