FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000611245> ?p ?o ?g. }

• W2000611245 endingPage "442" @default.
• W2000611245 startingPage "434" @default.
• W2000611245 abstract "The initiating somatic genetic events in chordoma development have not yet been identified. Most cytogenetically investigated chordomas have displayed near-diploid or moderately hypodiploid karyotypes, with several numerical and structural rearrangements. However, no consistent structural chromosome aberration has been reported. This is the first array-based study characterising DNA copy number changes in chordoma. Array comparative genomic hybridisation (aCGH) identified copy number alterations in all samples and imbalances affecting 5 or more out of the 21 investigated tumours were seen on all chromosomes. In general, deletions were more common than gains and no high-level amplification was found, supporting previous findings of primarily losses of large chromosomal regions as an important mechanism in chordoma development. Although small imbalances were commonly found, the vast majority of these were detected in single cases; no small deletion affecting all tumours could be discerned. However, the CDKN2A and CDKN2B loci in 9p21 were homo- or heterozygously lost in 70% of the tumours, a finding corroborated by fluorescence in situ hybridisation, suggesting that inactivation of these genes constitute an important step in chordoma development." @default.
• W2000611245 created "2016-06-24" @default.
• W2000611245 creator A5002093555 @default.
• W2000611245 creator A5003014435 @default.
• W2000611245 creator A5051788843 @default.
• W2000611245 creator A5056172056 @default.
• W2000611245 creator A5064842529 @default.
• W2000611245 creator A5065262675 @default.
• W2000611245 creator A5070841226 @default.
• W2000611245 creator A5074366700 @default.
• W2000611245 creator A5083498741 @default.
• W2000611245 creator A5086406942 @default.
• W2000611245 creator A5087007057 @default.
• W2000611245 date "2007-12-11" @default.
• W2000611245 modified "2023-10-12" @default.
• W2000611245 title "Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation" @default.
• W2000611245 cites W1969040720 @default.
• W2000611245 cites W1971335457 @default.
• W2000611245 cites W1978647823 @default.
• W2000611245 cites W1984489524 @default.
• W2000611245 cites W1988298018 @default.
• W2000611245 cites W1991348907 @default.
• W2000611245 cites W1995232954 @default.
• W2000611245 cites W1995739555 @default.
• W2000611245 cites W1998638130 @default.
• W2000611245 cites W2001432758 @default.
• W2000611245 cites W2007211768 @default.
• W2000611245 cites W2007659620 @default.
• W2000611245 cites W2007852760 @default.
• W2000611245 cites W2010617018 @default.
• W2000611245 cites W2016380812 @default.
• W2000611245 cites W2019769459 @default.
• W2000611245 cites W2022227305 @default.
• W2000611245 cites W2023070796 @default.
• W2000611245 cites W2032947725 @default.
• W2000611245 cites W2044043158 @default.
• W2000611245 cites W2056495027 @default.
• W2000611245 cites W2064269319 @default.
• W2000611245 cites W2068173439 @default.
• W2000611245 cites W2068359474 @default.
• W2000611245 cites W2077480850 @default.
• W2000611245 cites W2077665432 @default.
• W2000611245 cites W2079662405 @default.
• W2000611245 cites W2092194090 @default.
• W2000611245 cites W2092858940 @default.
• W2000611245 cites W2117520145 @default.
• W2000611245 cites W2129766055 @default.
• W2000611245 cites W2129799250 @default.
• W2000611245 cites W2134070848 @default.
• W2000611245 cites W2135557996 @default.
• W2000611245 cites W2171454878 @default.
• W2000611245 doi "https://doi.org/10.1038/sj.bjc.6604130" @default.
• W2000611245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2361468" @default.
• W2000611245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18071362" @default.
• W2000611245 hasPublicationYear "2007" @default.
• W2000611245 type Work @default.
• W2000611245 sameAs 2000611245 @default.
• W2000611245 citedByCount "100" @default.
• W2000611245 countsByYear W20006112452012 @default.
• W2000611245 countsByYear W20006112452013 @default.
• W2000611245 countsByYear W20006112452014 @default.
• W2000611245 countsByYear W20006112452015 @default.
• W2000611245 countsByYear W20006112452016 @default.
• W2000611245 countsByYear W20006112452017 @default.
• W2000611245 countsByYear W20006112452018 @default.
• W2000611245 countsByYear W20006112452019 @default.
• W2000611245 countsByYear W20006112452020 @default.
• W2000611245 countsByYear W20006112452021 @default.
• W2000611245 countsByYear W20006112452022 @default.
• W2000611245 countsByYear W20006112452023 @default.
• W2000611245 crossrefType "journal-article" @default.
• W2000611245 hasAuthorship W2000611245A5002093555 @default.
• W2000611245 hasAuthorship W2000611245A5003014435 @default.
• W2000611245 hasAuthorship W2000611245A5051788843 @default.
• W2000611245 hasAuthorship W2000611245A5056172056 @default.
• W2000611245 hasAuthorship W2000611245A5064842529 @default.
• W2000611245 hasAuthorship W2000611245A5065262675 @default.
• W2000611245 hasAuthorship W2000611245A5070841226 @default.
• W2000611245 hasAuthorship W2000611245A5074366700 @default.
• W2000611245 hasAuthorship W2000611245A5083498741 @default.
• W2000611245 hasAuthorship W2000611245A5086406942 @default.
• W2000611245 hasAuthorship W2000611245A5087007057 @default.
• W2000611245 hasBestOaLocation W20006112451 @default.
• W2000611245 hasConcept C104317684 @default.
• W2000611245 hasConcept C124942203 @default.
• W2000611245 hasConcept C134305767 @default.
• W2000611245 hasConcept C142724271 @default.
• W2000611245 hasConcept C143191323 @default.
• W2000611245 hasConcept C2776300330 @default.
• W2000611245 hasConcept C2777542201 @default.
• W2000611245 hasConcept C2780265364 @default.
• W2000611245 hasConcept C2781190729 @default.
• W2000611245 hasConcept C30481170 @default.
• W2000611245 hasConcept C53226629 @default.
• W2000611245 hasConcept C54355233 @default.
• W2000611245 hasConcept C71924100 @default.
• W2000611245 hasConcept C84597430 @default.
• W2000611245 hasConcept C86803240 @default.

• next