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- W2000612034 abstract "A large number of trypsin inhibitors belonging to various types have been purified from different kinds of legumes. In this study, by using liquid chromatography, a Kunitz type trypsin inhibitor (KBTI) with a molecular weight of 20107.645 Da was purified from Korean large black soybeans. KBTI reduced the proteolytic activities of trypsin and α-chymotrypsin with the activity of ∼ 8520 BAEE units/mg and ∼ 24 BTEE units/mg, respectively. It showed high thermal stability (0–100 °C) as well as stability over a large range of pH values (pH 3–11). Furthermore, KBTI inhibited HIV-1 reverse transcriptase activity with an IC50 value of 0.71 μM and induced the release of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-2 and interferon-γ at the mRNA level. KBTI exerted weak antiproliferative activity toward CNE-2 and HNE-2 nasopharyngeal cancer cells, MCF-7 breast cancer cells, and Hep G2 hepatoma cells. KBTI was destitute of mitogenic, ribonuclease and antifungal activities." @default.
- W2000612034 created "2016-06-24" @default.
- W2000612034 creator A5035780833 @default.
- W2000612034 creator A5048788845 @default.
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- W2000612034 date "2010-03-01" @default.
- W2000612034 modified "2023-09-23" @default.
- W2000612034 title "Thermostable Kunitz trypsin inhibitor with cytokine inducing, antitumor and HIV-1 reverse transcriptase inhibitory activities from Korean large black soybeans" @default.
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- W2000612034 doi "https://doi.org/10.1016/j.jbiosc.2009.08.483" @default.
- W2000612034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20159565" @default.
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