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• W2000612081 abstract "Protein kinases C are a family of serine threonine protein kinases that play key roles in extracellular signal transduction. Inappropriate activation of protein kinase C has been implicated in the pathophysiology of many diseases, including diabetes mellitus. Indeed, protein kinase C activation may contribute not only to the pathogenesis of diabetic complications such as nephropathy and retinopathy, but also to insulin resistance. Growing awareness that protein kinase C isoforms subserve specific subcellular functions has led to the development of isoform-specific inhibitors, which may be useful investigational tools and therapeutic agents for attenuating the effects of inappropriate protein kinase C activity. Here we review the role played by protein kinases C in diabetic nephropathy and the recent progress that has been made to modulate its activity using specific inhibitors." @default.
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• W2000612081 date "1998-09-01" @default.
• W2000612081 modified "2023-10-18" @default.
• W2000612081 title "Protein kinases C" @default.
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• W2000612081 doi "https://doi.org/10.1097/00041552-199809000-00013" @default.
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