Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000612341> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2000612341 abstract "A series of analogues of neuropeptide tyrosine (NPY) was synthesized by solid-phase peptide synthesis using BOP as a coupling reagent for the complete synthesis. A structure-activity study of the N-terminal portion of the molecule was performed with the analogues obtained by the successive replacement of the first 10 amino acids by the residue L-alanine. NPY and its analogues [Ala1-10]hNPY were tested for their potency on rat vas deferens and for their affinity to central nervous system receptors on a rat brain membrane preparation. The results suggest that the hypothetical polyproline type II helix structure of the N-terminal segment is involved in both potency and affinity. Indeed, the substitution by L-Ala of proline residues in position 2, 5, or 8 showed important losses of activity and affinity. The more important losses were observed with the replacement of Pro-5 or Pro-8. A critical loss of potency of hNPY was also observed after the substitution of the Tyr-1 residue by L-Ala, thus confirming the important role played by this residue for the full expression of the biological activity of NPY." @default.
- W2000612341 created "2016-06-24" @default.
- W2000612341 creator A5016543815 @default.
- W2000612341 creator A5029065395 @default.
- W2000612341 creator A5031224564 @default.
- W2000612341 creator A5055183128 @default.
- W2000612341 creator A5012126424 @default.
- W2000612341 date "1990-11-01" @default.
- W2000612341 modified "2023-10-02" @default.
- W2000612341 title "Structural Study of the N-Terminal Segment of Neuropeptide-Tyrosine" @default.
- W2000612341 cites W2000406033 @default.
- W2000612341 cites W2012407085 @default.
- W2000612341 cites W2030085166 @default.
- W2000612341 cites W2033183190 @default.
- W2000612341 cites W2062531547 @default.
- W2000612341 cites W2073729727 @default.
- W2000612341 cites W2116464907 @default.
- W2000612341 doi "https://doi.org/10.1111/j.1749-6632.1990.tb48952.x" @default.
- W2000612341 hasPublicationYear "1990" @default.
- W2000612341 type Work @default.
- W2000612341 sameAs 2000612341 @default.
- W2000612341 citedByCount "0" @default.
- W2000612341 crossrefType "journal-article" @default.
- W2000612341 hasAuthorship W2000612341A5012126424 @default.
- W2000612341 hasAuthorship W2000612341A5016543815 @default.
- W2000612341 hasAuthorship W2000612341A5029065395 @default.
- W2000612341 hasAuthorship W2000612341A5031224564 @default.
- W2000612341 hasAuthorship W2000612341A5055183128 @default.
- W2000612341 hasConcept C109300003 @default.
- W2000612341 hasConcept C116073593 @default.
- W2000612341 hasConcept C118303440 @default.
- W2000612341 hasConcept C170493617 @default.
- W2000612341 hasConcept C185592680 @default.
- W2000612341 hasConcept C202751555 @default.
- W2000612341 hasConcept C2776165026 @default.
- W2000612341 hasConcept C2779281246 @default.
- W2000612341 hasConcept C2779815552 @default.
- W2000612341 hasConcept C2779856020 @default.
- W2000612341 hasConcept C2781338088 @default.
- W2000612341 hasConcept C515207424 @default.
- W2000612341 hasConcept C55493867 @default.
- W2000612341 hasConcept C57992300 @default.
- W2000612341 hasConcept C71240020 @default.
- W2000612341 hasConcept C93984277 @default.
- W2000612341 hasConceptScore W2000612341C109300003 @default.
- W2000612341 hasConceptScore W2000612341C116073593 @default.
- W2000612341 hasConceptScore W2000612341C118303440 @default.
- W2000612341 hasConceptScore W2000612341C170493617 @default.
- W2000612341 hasConceptScore W2000612341C185592680 @default.
- W2000612341 hasConceptScore W2000612341C202751555 @default.
- W2000612341 hasConceptScore W2000612341C2776165026 @default.
- W2000612341 hasConceptScore W2000612341C2779281246 @default.
- W2000612341 hasConceptScore W2000612341C2779815552 @default.
- W2000612341 hasConceptScore W2000612341C2779856020 @default.
- W2000612341 hasConceptScore W2000612341C2781338088 @default.
- W2000612341 hasConceptScore W2000612341C515207424 @default.
- W2000612341 hasConceptScore W2000612341C55493867 @default.
- W2000612341 hasConceptScore W2000612341C57992300 @default.
- W2000612341 hasConceptScore W2000612341C71240020 @default.
- W2000612341 hasConceptScore W2000612341C93984277 @default.
- W2000612341 hasLocation W20006123411 @default.
- W2000612341 hasOpenAccess W2000612341 @default.
- W2000612341 hasPrimaryLocation W20006123411 @default.
- W2000612341 hasRelatedWork W138372191 @default.
- W2000612341 hasRelatedWork W1971786824 @default.
- W2000612341 hasRelatedWork W1988335071 @default.
- W2000612341 hasRelatedWork W1991143739 @default.
- W2000612341 hasRelatedWork W1991849045 @default.
- W2000612341 hasRelatedWork W1992040316 @default.
- W2000612341 hasRelatedWork W1992718611 @default.
- W2000612341 hasRelatedWork W2007812836 @default.
- W2000612341 hasRelatedWork W2021231881 @default.
- W2000612341 hasRelatedWork W2032956752 @default.
- W2000612341 hasRelatedWork W2059338066 @default.
- W2000612341 hasRelatedWork W2063781291 @default.
- W2000612341 hasRelatedWork W2069853754 @default.
- W2000612341 hasRelatedWork W2073147337 @default.
- W2000612341 hasRelatedWork W2162172962 @default.
- W2000612341 hasRelatedWork W2247850076 @default.
- W2000612341 hasRelatedWork W2371868195 @default.
- W2000612341 hasRelatedWork W2404157127 @default.
- W2000612341 hasRelatedWork W2424075234 @default.
- W2000612341 hasRelatedWork W2899876501 @default.
- W2000612341 isParatext "false" @default.
- W2000612341 isRetracted "false" @default.
- W2000612341 magId "2000612341" @default.
- W2000612341 workType "article" @default.