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• W2000613190 abstract "Epigenetics is the study of heritability not dependent on DNA sequence. The human epigenome includes covalent chemical modifications of DNA nucleotides and histone proteins; both are reversible and heritable. Other epigenetic regulators include noncoding RNAs (ncRNAs). These regulators allow for differential gene expression in diverse tissues despite all cells having the same genomic DNA sequence. Working synergistically, they control chromatin compaction and play crucial roles in embryogenesis, X-chromosome inactivation, and imprinting, and are important in the development and homeostasis of the nervous system. The authors thank Steven D. Orwoll for preparation of the illustrations." @default.
• W2000613190 created "2016-06-24" @default.
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• W2000613190 date "2014-04-23" @default.
• W2000613190 modified "2023-09-24" @default.
• W2000613190 title "Epigenetic regulation: Basic concepts and relevance to neurologic disease" @default.
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• W2000613190 doi "https://doi.org/10.1212/wnl.0000000000000440" @default.
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