FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000614198> ?p ?o ?g. }

• W2000614198 endingPage "943" @default.
• W2000614198 startingPage "934" @default.
• W2000614198 abstract "BackgroundDespite widespread interest in stem cells, their clinical application is largely limited owing to safety and cost concerns. We intended to overcome these limitations by evaluating whether the secretome of human adipose tissue-derived stem cells (ASCs) could be used to reverse ischemia/reperfusion (IR) injury in mice.MethodsAfter establishment of hepatic IR injury in BALB/c mice, the mice were infused with saline solution (saline group), 1.0 × 106 human ASCs (ASC group), 25-fold–concentrated ASC-conditioned medium (ASC-secretome group), which was the same volume as used for the ASC infusion, or concentrated control medium (medium-only group). After reperfusion, we obtained serum and liver specimens and compared parameters reflecting the degree of injury and mechanisms between the groups.ResultsAt 6 hours after reperfusion, serum interleukin (IL)-6 levels were decreased in both ASC and ASC-secretome groups (P < .05). At 12 and 24 hours after reperfusion, both ASC and ASC-secretome groups also demonstrated lesser histologic scores than did their controls (P < .05). In addition, the decreases in the expression of the cell adhesion markers intercellular adhesion molecule-1 and platelet–endothelial cell adhesion molecule-1 and in neutrophil infiltration into the liver were noted in the ASC-secretome group as well as in the ASC group.ConclusionASC and ASC-secretome infusions both alleviated liver damage and improved the liver microenvironment after hepatic IR injury. Our results indicate that the therapeutic potential of ASCs may result from a paracrine effect mediated by the ASC secretome; our work suggests a novel secretome-based therapeutic strategy to treat hepatic IR injury. Despite widespread interest in stem cells, their clinical application is largely limited owing to safety and cost concerns. We intended to overcome these limitations by evaluating whether the secretome of human adipose tissue-derived stem cells (ASCs) could be used to reverse ischemia/reperfusion (IR) injury in mice. After establishment of hepatic IR injury in BALB/c mice, the mice were infused with saline solution (saline group), 1.0 × 106 human ASCs (ASC group), 25-fold–concentrated ASC-conditioned medium (ASC-secretome group), which was the same volume as used for the ASC infusion, or concentrated control medium (medium-only group). After reperfusion, we obtained serum and liver specimens and compared parameters reflecting the degree of injury and mechanisms between the groups. At 6 hours after reperfusion, serum interleukin (IL)-6 levels were decreased in both ASC and ASC-secretome groups (P < .05). At 12 and 24 hours after reperfusion, both ASC and ASC-secretome groups also demonstrated lesser histologic scores than did their controls (P < .05). In addition, the decreases in the expression of the cell adhesion markers intercellular adhesion molecule-1 and platelet–endothelial cell adhesion molecule-1 and in neutrophil infiltration into the liver were noted in the ASC-secretome group as well as in the ASC group. ASC and ASC-secretome infusions both alleviated liver damage and improved the liver microenvironment after hepatic IR injury. Our results indicate that the therapeutic potential of ASCs may result from a paracrine effect mediated by the ASC secretome; our work suggests a novel secretome-based therapeutic strategy to treat hepatic IR injury." @default.
• W2000614198 created "2016-06-24" @default.
• W2000614198 creator A5032958224 @default.
• W2000614198 creator A5082684287 @default.
• W2000614198 creator A5084180627 @default.
• W2000614198 date "2015-05-01" @default.
• W2000614198 modified "2023-10-06" @default.
• W2000614198 title "Secretome from human adipose-derived stem cells protects mouse liver from hepatic ischemia–reperfusion injury" @default.
• W2000614198 cites W1506799643 @default.
• W2000614198 cites W1528681991 @default.
• W2000614198 cites W1540238567 @default.
• W2000614198 cites W1564275273 @default.
• W2000614198 cites W162447880 @default.
• W2000614198 cites W1801410338 @default.
• W2000614198 cites W1879141735 @default.
• W2000614198 cites W1910349427 @default.
• W2000614198 cites W1970665368 @default.
• W2000614198 cites W1983663906 @default.
• W2000614198 cites W1987767880 @default.
• W2000614198 cites W1990919357 @default.
• W2000614198 cites W1991501943 @default.
• W2000614198 cites W1992723596 @default.
• W2000614198 cites W1997984658 @default.
• W2000614198 cites W2006488152 @default.
• W2000614198 cites W2009599333 @default.
• W2000614198 cites W2013066063 @default.
• W2000614198 cites W2017945589 @default.
• W2000614198 cites W2019237351 @default.
• W2000614198 cites W2025650191 @default.
• W2000614198 cites W2028524718 @default.
• W2000614198 cites W2031696959 @default.
• W2000614198 cites W2041912799 @default.
• W2000614198 cites W2047654273 @default.
• W2000614198 cites W2048354810 @default.
• W2000614198 cites W2048805706 @default.
• W2000614198 cites W2056879548 @default.
• W2000614198 cites W2064329624 @default.
• W2000614198 cites W2068756999 @default.
• W2000614198 cites W2076284721 @default.
• W2000614198 cites W2076419813 @default.
• W2000614198 cites W2078243585 @default.
• W2000614198 cites W2080316457 @default.
• W2000614198 cites W2080397970 @default.
• W2000614198 cites W2085554170 @default.
• W2000614198 cites W2092368313 @default.
• W2000614198 cites W2095764834 @default.
• W2000614198 cites W2116500923 @default.
• W2000614198 cites W2118458879 @default.
• W2000614198 cites W2136279247 @default.
• W2000614198 cites W2137066867 @default.
• W2000614198 cites W2159999899 @default.
• W2000614198 cites W2321700180 @default.
• W2000614198 cites W2344640730 @default.
• W2000614198 doi "https://doi.org/10.1016/j.surg.2014.12.016" @default.
• W2000614198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25704431" @default.
• W2000614198 hasPublicationYear "2015" @default.
• W2000614198 type Work @default.
• W2000614198 sameAs 2000614198 @default.
• W2000614198 citedByCount "32" @default.
• W2000614198 countsByYear W20006141982015 @default.
• W2000614198 countsByYear W20006141982016 @default.
• W2000614198 countsByYear W20006141982017 @default.
• W2000614198 countsByYear W20006141982018 @default.
• W2000614198 countsByYear W20006141982019 @default.
• W2000614198 countsByYear W20006141982020 @default.
• W2000614198 countsByYear W20006141982021 @default.
• W2000614198 countsByYear W20006141982022 @default.
• W2000614198 countsByYear W20006141982023 @default.
• W2000614198 crossrefType "journal-article" @default.
• W2000614198 hasAuthorship W2000614198A5032958224 @default.
• W2000614198 hasAuthorship W2000614198A5082684287 @default.
• W2000614198 hasAuthorship W2000614198A5084180627 @default.
• W2000614198 hasBestOaLocation W20006141981 @default.
• W2000614198 hasConcept C126322002 @default.
• W2000614198 hasConcept C142724271 @default.
• W2000614198 hasConcept C16224149 @default.
• W2000614198 hasConcept C16685009 @default.
• W2000614198 hasConcept C171089720 @default.
• W2000614198 hasConcept C203014093 @default.
• W2000614198 hasConcept C2776637226 @default.
• W2000614198 hasConcept C2777397205 @default.
• W2000614198 hasConcept C2780114680 @default.
• W2000614198 hasConcept C28328180 @default.
• W2000614198 hasConcept C541997718 @default.
• W2000614198 hasConcept C71924100 @default.
• W2000614198 hasConcept C86803240 @default.
• W2000614198 hasConcept C95444343 @default.
• W2000614198 hasConceptScore W2000614198C126322002 @default.
• W2000614198 hasConceptScore W2000614198C142724271 @default.
• W2000614198 hasConceptScore W2000614198C16224149 @default.
• W2000614198 hasConceptScore W2000614198C16685009 @default.
• W2000614198 hasConceptScore W2000614198C171089720 @default.
• W2000614198 hasConceptScore W2000614198C203014093 @default.
• W2000614198 hasConceptScore W2000614198C2776637226 @default.
• W2000614198 hasConceptScore W2000614198C2777397205 @default.
• W2000614198 hasConceptScore W2000614198C2780114680 @default.
• W2000614198 hasConceptScore W2000614198C28328180 @default.
• W2000614198 hasConceptScore W2000614198C541997718 @default.

• next