FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000615271> ?p ?o ?g. }

• W2000615271 endingPage "77" @default.
• W2000615271 startingPage "57" @default.
• W2000615271 abstract "The goal of immunotherapy is to stimulate the immune system by modification of tumor cells or expansion of lymphocytes which respond specifically to tumor antigens. In this study, we will apply techniques of direct gene transfer to enhance the immune response against tumors in vivo. Patients with advanced cancer who have failed all effective therapy will be treated by injection of a DNA/liposome complex directly within the tumor. DNA will be used which encodes a heterodimeric cell surface protein recognized in the transplantation response. These genes include the HLA-B7 histocompatibility antigen and β-2 microglobulin gene in a non-viral eukaryotic expression vector plasmid. For this vector, a safe and effective dose to introduce this recombinant gene in HLA-B7¯ patients will be established. HLA-B7 expression will be confirmed in vivo, and the immune response stimulated by the expression of this antigen will be characterized. We will also determine whether this treatment facilitates tumor regression alone or in combination with other treatment modalities. This study will employ a similar strategy to our previous gene therapy protocol, but employs four improvements in technology, including more efficacious liposomes, optimized vector expression, catheter delivery and application to other several types of cancer. These studies will facilitate the development of other approaches, using different recombinant genes or in combination with cytokines or adoptive T cell therapy, to augment tumor immunity, and allow for greater potential efficacy. This method will also establish the safety of this non-viral approach to gene therapy, which could potentially be extended to treat a variety of other human diseases. Many types of cancer cannot be cured by traditional medical treatments, including drugs, surgery, or radiation. In this study, an experimental treatment will be offered that may help to fight this disease. We will attempt to induce tumor regression by the introduction of genetic material that directs the synthesis of proteins which stimulate the immune system. The genetic material, DNA, will be introduced directly into the tumor by mixing it with fat bodies, or liposomes, and this mixture will be injected into the tumor or delivered by a catheter. The DNA will be taken into cells and cause them to produce proteins that stimulate tissue rejection. These proteins, called histocompatibility proteins, cause cells which contain it to be recognized as foreign by the immune system. In some cases, another immune stimulatory protein, interleukin-2, will also be included. The goal of the treatment is to stimulate the immune system to attack and kill the tumor. In this study, we will determine a safe and effective dose to administer the DNA liposome complex. Increasing amounts of this complex will be used in different patient populations. If no side effects are observed, repeated treatments will be instituted. The expression and nature of the immune response will also be characterized. This treatment may provide a therapeutic effect in cancer and could be applied to the treatment of other diseases." @default.
• W2000615271 created "2016-06-24" @default.
• W2000615271 creator A5011163683 @default.
• W2000615271 creator A5014713398 @default.
• W2000615271 creator A5020818775 @default.
• W2000615271 creator A5042603807 @default.
• W2000615271 creator A5046279796 @default.
• W2000615271 creator A5056647850 @default.
• W2000615271 creator A5061211279 @default.
• W2000615271 creator A5067078236 @default.
• W2000615271 creator A5067266240 @default.
• W2000615271 date "1994-01-01" @default.
• W2000615271 modified "2023-10-14" @default.
• W2000615271 title "Immunotherapy for Cancer by Direct Gene Transfer into Tumors. Howard Hughes Medical Institute Research Laboratories, Ann Arbor, Michigan" @default.
• W2000615271 cites W1481598923 @default.
• W2000615271 cites W1493114553 @default.
• W2000615271 cites W1547530432 @default.
• W2000615271 cites W1578312240 @default.
• W2000615271 cites W1610398404 @default.
• W2000615271 cites W1643040145 @default.
• W2000615271 cites W1965219484 @default.
• W2000615271 cites W1965319333 @default.
• W2000615271 cites W1973291904 @default.
• W2000615271 cites W1973312385 @default.
• W2000615271 cites W1975568557 @default.
• W2000615271 cites W1984793704 @default.
• W2000615271 cites W1987749055 @default.
• W2000615271 cites W1989775015 @default.
• W2000615271 cites W1990668606 @default.
• W2000615271 cites W1996671893 @default.
• W2000615271 cites W2001332902 @default.
• W2000615271 cites W2006253272 @default.
• W2000615271 cites W2011527345 @default.
• W2000615271 cites W2019449154 @default.
• W2000615271 cites W2029793114 @default.
• W2000615271 cites W2034642422 @default.
• W2000615271 cites W2044156111 @default.
• W2000615271 cites W2048325240 @default.
• W2000615271 cites W2053374868 @default.
• W2000615271 cites W2057339816 @default.
• W2000615271 cites W2057577614 @default.
• W2000615271 cites W2057669087 @default.
• W2000615271 cites W2059191530 @default.
• W2000615271 cites W2073276808 @default.
• W2000615271 cites W2079332181 @default.
• W2000615271 cites W2087714540 @default.
• W2000615271 cites W2094465569 @default.
• W2000615271 cites W2098552669 @default.
• W2000615271 cites W2105049742 @default.
• W2000615271 cites W2130537353 @default.
• W2000615271 cites W2130901389 @default.
• W2000615271 cites W2136593550 @default.
• W2000615271 cites W2140330161 @default.
• W2000615271 cites W2319534054 @default.
• W2000615271 cites W2322553446 @default.
• W2000615271 cites W2327445995 @default.
• W2000615271 cites W2335365056 @default.
• W2000615271 cites W4313311365 @default.
• W2000615271 doi "https://doi.org/10.1089/hum.1994.5.1-57" @default.
• W2000615271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8155772" @default.
• W2000615271 hasPublicationYear "1994" @default.
• W2000615271 type Work @default.
• W2000615271 sameAs 2000615271 @default.
• W2000615271 citedByCount "82" @default.
• W2000615271 countsByYear W20006152712016 @default.
• W2000615271 countsByYear W20006152712017 @default.
• W2000615271 countsByYear W20006152712020 @default.
• W2000615271 crossrefType "journal-article" @default.
• W2000615271 hasAuthorship W2000615271A5011163683 @default.
• W2000615271 hasAuthorship W2000615271A5014713398 @default.
• W2000615271 hasAuthorship W2000615271A5020818775 @default.
• W2000615271 hasAuthorship W2000615271A5042603807 @default.
• W2000615271 hasAuthorship W2000615271A5046279796 @default.
• W2000615271 hasAuthorship W2000615271A5056647850 @default.
• W2000615271 hasAuthorship W2000615271A5061211279 @default.
• W2000615271 hasAuthorship W2000615271A5067078236 @default.
• W2000615271 hasAuthorship W2000615271A5067266240 @default.
• W2000615271 hasConcept C104317684 @default.
• W2000615271 hasConcept C111599444 @default.
• W2000615271 hasConcept C121608353 @default.
• W2000615271 hasConcept C126322002 @default.
• W2000615271 hasConcept C135983454 @default.
• W2000615271 hasConcept C147483822 @default.
• W2000615271 hasConcept C167508917 @default.
• W2000615271 hasConcept C188280979 @default.
• W2000615271 hasConcept C203014093 @default.
• W2000615271 hasConcept C207936829 @default.
• W2000615271 hasConcept C2776090121 @default.
• W2000615271 hasConcept C2777701055 @default.
• W2000615271 hasConcept C2780674031 @default.
• W2000615271 hasConcept C2780801004 @default.
• W2000615271 hasConcept C2911091166 @default.
• W2000615271 hasConcept C32470452 @default.
• W2000615271 hasConcept C40767141 @default.
• W2000615271 hasConcept C502942594 @default.
• W2000615271 hasConcept C54355233 @default.
• W2000615271 hasConcept C71924100 @default.
• W2000615271 hasConcept C86803240 @default.

• next