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• W2000615511 abstract "A new flavanone derivative, malaysianone A (1), four prenylated flavanones, 6-prenyl-3′-methoxyeriodictyol (2), nymphaeol B (3), nymphaeol C (4) and 6-farnesyl-3′,4′,5,7-tetrahydroxyflavanone (5), and two coumarins, 5,7-dihydroxycoumarin (6) and scopoletin (7), were isolated from the dichloromethane extract of the inflorescences of Macaranga triloba. The structures of these compounds were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR and mass spectrometry. The cytotoxic activity of the compounds was tested against several cell lines, with 5 inhibiting very strongly the growth of HeLa and HL-60 cells (IC50: 1.3 μg/ml and 3.3 μg/ml, respectively). Compound 5 also showed strong antiplasmodial activity (IC50: 0.06 μM)." @default.
• W2000615511 created "2016-06-24" @default.
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• W2000615511 date "2012-07-01" @default.
• W2000615511 modified "2023-10-16" @default.
• W2000615511 title "Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba" @default.
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• W2000615511 doi "https://doi.org/10.1016/j.fitote.2012.04.020" @default.
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