Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000617900> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000617900 abstract "The purpose of this study was to characterize the mechanisms involved in the placental clearance of hypoxanthine.Uptake of isotope-labeled compounds was measured in the in situ perfused guinea pig placenta and in membrane vesicles isolated from the human syncytiotrophoblast.In the guinea pig hypoxanthine uptake (from the fetal circulation) proceeded by a saturable (Michaelis constant approximately 90 mumol/L), sodium-dependent mechanism that was inhibited by 19 mmol/L papaverine but not by 10 mumol/L nitrobenzylthioinosine or 10 mmol/L uridine. Uridine uptake was blocked by nitrobenzylthioinosine but not by papaverine or 4 mmol/L hypoxanthine. In human brush-border (maternal-facing) membrane vesicles hypoxanthine influx was sodium independent and best fitted to a saturable (Michaelis constant 290 +/- 45 mumol/L) plus a linear component. Saturable influx was blocked by papaverine but not by nitrobenzylthioinosine. Uridine uptake was not affected by 4 mmol/L hypoxanthine. Mediated hypoxanthine uptake by human basal (fetal-facing) membrane vesicles was not detected.At both placental blood-tissue interfaces hypoxanthine transport occurs through specific mechanisms that are different from the nucleoside transporters." @default.
- W2000617900 created "2016-06-24" @default.
- W2000617900 creator A5003717548 @default.
- W2000617900 date "1994-07-01" @default.
- W2000617900 modified "2023-09-26" @default.
- W2000617900 title "Hypoxanthine transport in the guinea pig and human placenta is a carrier-mediated process that does not involve nucleoside transporters" @default.
- W2000617900 cites W124946611 @default.
- W2000617900 cites W1490848194 @default.
- W2000617900 cites W1580759730 @default.
- W2000617900 cites W174852314 @default.
- W2000617900 cites W1966785345 @default.
- W2000617900 cites W1976365732 @default.
- W2000617900 cites W1984128196 @default.
- W2000617900 cites W1988620818 @default.
- W2000617900 cites W1992516247 @default.
- W2000617900 cites W1993938897 @default.
- W2000617900 cites W2014512548 @default.
- W2000617900 cites W2056685473 @default.
- W2000617900 cites W2063025507 @default.
- W2000617900 cites W2072335091 @default.
- W2000617900 cites W2079992088 @default.
- W2000617900 cites W2081998602 @default.
- W2000617900 cites W2083313025 @default.
- W2000617900 cites W2085176492 @default.
- W2000617900 cites W2118284156 @default.
- W2000617900 cites W2398153055 @default.
- W2000617900 cites W2400093226 @default.
- W2000617900 cites W2412666196 @default.
- W2000617900 cites W2413790300 @default.
- W2000617900 cites W181498255 @default.
- W2000617900 doi "https://doi.org/10.1016/s0002-9378(94)70086-9" @default.
- W2000617900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8030685" @default.
- W2000617900 hasPublicationYear "1994" @default.
- W2000617900 type Work @default.
- W2000617900 sameAs 2000617900 @default.
- W2000617900 citedByCount "13" @default.
- W2000617900 countsByYear W20006179002017 @default.
- W2000617900 crossrefType "journal-article" @default.
- W2000617900 hasAuthorship W2000617900A5003717548 @default.
- W2000617900 hasConcept C104317684 @default.
- W2000617900 hasConcept C130316041 @default.
- W2000617900 hasConcept C134018914 @default.
- W2000617900 hasConcept C149011108 @default.
- W2000617900 hasConcept C172680121 @default.
- W2000617900 hasConcept C181199279 @default.
- W2000617900 hasConcept C185592680 @default.
- W2000617900 hasConcept C2776543447 @default.
- W2000617900 hasConcept C2776952824 @default.
- W2000617900 hasConcept C2776953305 @default.
- W2000617900 hasConcept C2779234561 @default.
- W2000617900 hasConcept C2779315647 @default.
- W2000617900 hasConcept C2780549722 @default.
- W2000617900 hasConcept C2781116151 @default.
- W2000617900 hasConcept C2781259782 @default.
- W2000617900 hasConcept C41625074 @default.
- W2000617900 hasConcept C54355233 @default.
- W2000617900 hasConcept C55493867 @default.
- W2000617900 hasConcept C67705224 @default.
- W2000617900 hasConcept C86803240 @default.
- W2000617900 hasConceptScore W2000617900C104317684 @default.
- W2000617900 hasConceptScore W2000617900C130316041 @default.
- W2000617900 hasConceptScore W2000617900C134018914 @default.
- W2000617900 hasConceptScore W2000617900C149011108 @default.
- W2000617900 hasConceptScore W2000617900C172680121 @default.
- W2000617900 hasConceptScore W2000617900C181199279 @default.
- W2000617900 hasConceptScore W2000617900C185592680 @default.
- W2000617900 hasConceptScore W2000617900C2776543447 @default.
- W2000617900 hasConceptScore W2000617900C2776952824 @default.
- W2000617900 hasConceptScore W2000617900C2776953305 @default.
- W2000617900 hasConceptScore W2000617900C2779234561 @default.
- W2000617900 hasConceptScore W2000617900C2779315647 @default.
- W2000617900 hasConceptScore W2000617900C2780549722 @default.
- W2000617900 hasConceptScore W2000617900C2781116151 @default.
- W2000617900 hasConceptScore W2000617900C2781259782 @default.
- W2000617900 hasConceptScore W2000617900C41625074 @default.
- W2000617900 hasConceptScore W2000617900C54355233 @default.
- W2000617900 hasConceptScore W2000617900C55493867 @default.
- W2000617900 hasConceptScore W2000617900C67705224 @default.
- W2000617900 hasConceptScore W2000617900C86803240 @default.
- W2000617900 hasLocation W20006179001 @default.
- W2000617900 hasLocation W20006179002 @default.
- W2000617900 hasOpenAccess W2000617900 @default.
- W2000617900 hasPrimaryLocation W20006179001 @default.
- W2000617900 hasRelatedWork W1537680617 @default.
- W2000617900 hasRelatedWork W160024026 @default.
- W2000617900 hasRelatedWork W1621443637 @default.
- W2000617900 hasRelatedWork W1951654495 @default.
- W2000617900 hasRelatedWork W1968115961 @default.
- W2000617900 hasRelatedWork W1978992740 @default.
- W2000617900 hasRelatedWork W1982325051 @default.
- W2000617900 hasRelatedWork W2000617900 @default.
- W2000617900 hasRelatedWork W2048971949 @default.
- W2000617900 hasRelatedWork W2095528918 @default.
- W2000617900 isParatext "false" @default.
- W2000617900 isRetracted "false" @default.
- W2000617900 magId "2000617900" @default.
- W2000617900 workType "article" @default.