FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000618086> ?p ?o ?g. }

• W2000618086 endingPage "842" @default.
• W2000618086 startingPage "835" @default.
• W2000618086 abstract "Treatment for chronic hepatitis B (CHB) has improved over the last 10 years mainly due to the development of effective oral antiviral agents [nucleoside/nucleotide analogs (NUCs)].The aim of the present study is to identify the frequency and major patterns of resistance to the hepatitis B virus (HBV) in a Turkish population of CHB patients treated with NUCs using add-on and switch therapy strategies.The investigation involved a total of 194 patients (88 were treated using add-on therapy, and 106 were treated using switch therapy). We analyzed the HBV polymerase gene by amplification and direct sequencing procedures.Primary drug-resistance mutations were detected in 84 patients (43%; 42 in add-on therapy, and 42 in switch therapy) taking lamivudine (LAM), 10 patients (5%; 6 in add-on therapy, and 4 in switch therapy) taking entecavir (ETV), and 16 patients (8%; 8 in add-on therapy, and 8 in switch therapy) taking adefovir (ADV). The most common LAM and ETV resistance mutations were rtM204I/V, rtL180M and rtT184A/I/S, respectively, while rtA181T/V and rtN236T substitutions were the most frequently observed ADV resistance mutations.Patients with CHB who developed NUC resistance were managed using 2 different rescue strategies. The frequency and mutation pattern of resistance were similar in patients treated with add-on and switch strategies. These findings may be helpful in the management of rescue strategies in LAM-resistant patients." @default.
• W2000618086 created "2016-06-24" @default.
• W2000618086 creator A5003156701 @default.
• W2000618086 creator A5015427454 @default.
• W2000618086 creator A5043609167 @default.
• W2000618086 date "2011-09-30" @default.
• W2000618086 modified "2023-10-01" @default.
• W2000618086 title "Frequency and Mutation Patterns of Resistance in Patients with Chronic Hepatitis B Infection Treated with Nucleos(t)ide Analogues in Add-On and Switch Strategies" @default.
• W2000618086 cites W124116101 @default.
• W2000618086 cites W1493372259 @default.
• W2000618086 cites W1526671947 @default.
• W2000618086 cites W1541404344 @default.
• W2000618086 cites W1820475767 @default.
• W2000618086 cites W1976762454 @default.
• W2000618086 cites W1983113514 @default.
• W2000618086 cites W1984898374 @default.
• W2000618086 cites W1996434058 @default.
• W2000618086 cites W1996800338 @default.
• W2000618086 cites W1997813753 @default.
• W2000618086 cites W2006698257 @default.
• W2000618086 cites W2011269097 @default.
• W2000618086 cites W2012774039 @default.
• W2000618086 cites W2023509812 @default.
• W2000618086 cites W2040289109 @default.
• W2000618086 cites W2046089461 @default.
• W2000618086 cites W2046151142 @default.
• W2000618086 cites W2047312769 @default.
• W2000618086 cites W2051306094 @default.
• W2000618086 cites W2051961789 @default.
• W2000618086 cites W2051976356 @default.
• W2000618086 cites W2059481170 @default.
• W2000618086 cites W2061505027 @default.
• W2000618086 cites W2064695462 @default.
• W2000618086 cites W2069441352 @default.
• W2000618086 cites W2073478615 @default.
• W2000618086 cites W2075559061 @default.
• W2000618086 cites W2088345510 @default.
• W2000618086 cites W2104969243 @default.
• W2000618086 cites W2110747022 @default.
• W2000618086 cites W2110941134 @default.
• W2000618086 cites W2115956200 @default.
• W2000618086 cites W2116584773 @default.
• W2000618086 cites W2118539769 @default.
• W2000618086 cites W2122853284 @default.
• W2000618086 cites W2126563189 @default.
• W2000618086 cites W2132043997 @default.
• W2000618086 cites W2138306213 @default.
• W2000618086 cites W2140116049 @default.
• W2000618086 cites W2145899386 @default.
• W2000618086 cites W2166274558 @default.
• W2000618086 cites W2181762296 @default.
• W2000618086 cites W2277126161 @default.
• W2000618086 cites W2392082701 @default.
• W2000618086 cites W65089870 @default.
• W2000618086 cites W1996792477 @default.
• W2000618086 cites W2739535516 @default.
• W2000618086 doi "https://doi.org/10.5812/kowsar.1735143x.775" @default.
• W2000618086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3234585" @default.
• W2000618086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22224083" @default.
• W2000618086 hasPublicationYear "2011" @default.
• W2000618086 type Work @default.
• W2000618086 sameAs 2000618086 @default.
• W2000618086 citedByCount "8" @default.
• W2000618086 countsByYear W20006180862012 @default.
• W2000618086 countsByYear W20006180862014 @default.
• W2000618086 countsByYear W20006180862015 @default.
• W2000618086 countsByYear W20006180862018 @default.
• W2000618086 countsByYear W20006180862019 @default.
• W2000618086 crossrefType "journal-article" @default.
• W2000618086 hasAuthorship W2000618086A5003156701 @default.
• W2000618086 hasAuthorship W2000618086A5015427454 @default.
• W2000618086 hasAuthorship W2000618086A5043609167 @default.
• W2000618086 hasBestOaLocation W20006180861 @default.
• W2000618086 hasConcept C104317684 @default.
• W2000618086 hasConcept C114851261 @default.
• W2000618086 hasConcept C126322002 @default.
• W2000618086 hasConcept C156719811 @default.
• W2000618086 hasConcept C159047783 @default.
• W2000618086 hasConcept C182707283 @default.
• W2000618086 hasConcept C2522874641 @default.
• W2000618086 hasConcept C2776175608 @default.
• W2000618086 hasConcept C2776999253 @default.
• W2000618086 hasConcept C2777382497 @default.
• W2000618086 hasConcept C2777869810 @default.
• W2000618086 hasConcept C2779517838 @default.
• W2000618086 hasConcept C2780593183 @default.
• W2000618086 hasConcept C2908647359 @default.
• W2000618086 hasConcept C3020491458 @default.
• W2000618086 hasConcept C49105822 @default.
• W2000618086 hasConcept C501734568 @default.
• W2000618086 hasConcept C54355233 @default.
• W2000618086 hasConcept C71924100 @default.
• W2000618086 hasConcept C86803240 @default.
• W2000618086 hasConcept C99454951 @default.
• W2000618086 hasConceptScore W2000618086C104317684 @default.
• W2000618086 hasConceptScore W2000618086C114851261 @default.
• W2000618086 hasConceptScore W2000618086C126322002 @default.
• W2000618086 hasConceptScore W2000618086C156719811 @default.

• next