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- W2000618706 abstract "Purpose: This paper uses pharmacokinetic analysis of 18-Fluoromisonidazole (FMISO) dynamic PET imaging to investigate if there is any correlation between tumor hypoxia (Ki), tumor-to-blood ratio (T/B) in late-time image, local blood perfusion (k1), and local vasculature fraction (β) for head-and-neck cancer patients. Methods and Materials: Newly diagnosed patients with head-and-neck cancer prior to chemotherapy or radiotherapy underwent dynamic FMISO-PET scan. The data was acquired in 3 consecutive PET/CT dynamic scan segments, with start acquisition time [0, 1, 2, 3, 4, 5, 10, 15, 20, 25, 90, 95, 180, 185] minutes, consisting of 5 frames in 1-minute frames, following by 5-minutes frames. The dynamic PET images were first registered with each other and then analyzed using Philips Resarch's Voxulus pharmacokinetic software. The (Ki, k1, β) kinetic parameter images were derived for each patient. Results: Nine head-and-neck cancer patients' data were analyzed. Representative images of FDG-PET (showing the tumor), CT (showing the anatomy), late-time FMISO-PET (showing T/B), and (Ki, k1, β) kinetic parameter images were shown consisting of a patient example with good concordance of tumor hypoxia and high T/B, one with concordance of no tumor hypoxia and low T/B, and one with ambiguity between tumor hypoxia and T/B. Scatter diagrams were plotted between each pair of T/B, Ki, k1, β and corresponding correlation coefficient computed. Conclusions: There is strong positive correlation between ROI's T/B and hypoxia index Ki. However, due to the statistical photon counting noise in PET imaging, and the amplification of noise in kinetic analysis, the direct correlation between individual pixel's T/B and hypoxia is not obvious. For a tumor ROI, there is slight negative correlation between k1 and Ki, moderate positive correlation between β and Ki, but no correlation between β and Ki. This work is supported in part by NIH PO1 CA115675." @default.
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- W2000618706 date "2009-06-01" @default.
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- W2000618706 title "WE-C-303A-03: Pharmacokinetic Analysis of Hypoxia 18-Fluoromisonidazole Dynamic PET Imaging in Head and Neck Cancer" @default.
- W2000618706 doi "https://doi.org/10.1118/1.3182481" @default.
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