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• W2000619620 abstract "Chemical studies of the Chinese herb Corydalis saxicola Bunting led to the isolation and identification of 14 alkaloids, 1–14. Seven of these compounds, 4–9 and 11, were obtained from this plant for the first time. Feruloylagmatine (7) is the first guanidine-type alkaloid to be identified in the family Papaveraceae and in dicotyledonous plants. All of the isolated compounds were assayed for inhibitory activity against human DNA topoisomerase I. A DNA cleavage assay demonstrated that these alkaloids specifically inhibit topoisomerase through stabilization of the enzyme–DNA complex. Among the isolated alkaloids, (−)-pallidine (8) and (−)-scoulerine (11) showed strong inhibitory activities toward topoisomerase I that were comparable to camptothecin, a typical topoisomerase I inhibitor. A preliminary structure–activity relationship study suggested that the quaternary ammonium ion might play an important role in topoisomerase I inhibition by the isoquinoline alkaloids. These data indicated that DNA topoisomerase I inhibition represents probably one of the anticarcinogenic mechanisms of C. saxicola." @default.
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• W2000619620 date "2008-07-01" @default.
• W2000619620 modified "2023-10-15" @default.
• W2000619620 title "DNA Topoisomerase I Inhibitory Alkaloids from<i>Corydalis saxicola</i>" @default.
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• W2000619620 doi "https://doi.org/10.1002/cbdv.200890121" @default.
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