FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000620661> ?p ?o ?g. }

• W2000620661 endingPage "1650" @default.
• W2000620661 startingPage "1643" @default.
• W2000620661 abstract "T cells from an HLA-DR11/DR12 responder were stimulated in mixed lymphocyte culture with cells carrying the DR1 antigen. After priming, T cells proliferated in response to both DR1-positive-stimulating cells and a peptide derived from a polymorphic region of the HLA-DR beta 1*0101 chain presented by responder's antigen-presenting cells (APC). The dominant epitope recognized by the primed T cells corresponded to residue 21-42 and was presented by the responder's HLA-DR12 antigen. The DR1 peptide-reactive T cells express T cell receptor V beta 3. The results demonstrate that allopeptides derived from the processing and presentation of donor major histocompatibility complex molecules by host-derived APC trigger alloreactivity. The frequency of T cells engaged in the indirect pathway of allorecognition is about 100-fold lower than that of T cells participating in the direct recognition of native HLA-DR antigen. However, indirect allorecognition may play an important role in chronic allograft rejection, a phenomenon that is mediated by the activation of T helper cells and of alloantibody-producing B cells." @default.
• W2000620661 created "2016-06-24" @default.
• W2000620661 creator A5003314954 @default.
• W2000620661 creator A5026609346 @default.
• W2000620661 creator A5044768554 @default.
• W2000620661 creator A5050919306 @default.
• W2000620661 creator A5057922195 @default.
• W2000620661 creator A5085281093 @default.
• W2000620661 creator A5089839640 @default.
• W2000620661 date "1993-06-01" @default.
• W2000620661 modified "2023-09-27" @default.
• W2000620661 title "Contribution of direct and indirect recognition pathways to T cell alloreactivity." @default.
• W2000620661 cites W1530825423 @default.
• W2000620661 cites W1931389520 @default.
• W2000620661 cites W1970498805 @default.
• W2000620661 cites W1976835122 @default.
• W2000620661 cites W1995593914 @default.
• W2000620661 cites W2002171452 @default.
• W2000620661 cites W2019819289 @default.
• W2000620661 cites W2027388097 @default.
• W2000620661 cites W2030391080 @default.
• W2000620661 cites W2033370352 @default.
• W2000620661 cites W2033592208 @default.
• W2000620661 cites W2037184580 @default.
• W2000620661 cites W2043263636 @default.
• W2000620661 cites W2060866032 @default.
• W2000620661 cites W2076274640 @default.
• W2000620661 cites W2083079495 @default.
• W2000620661 cites W2095849410 @default.
• W2000620661 cites W2127293742 @default.
• W2000620661 cites W2131618013 @default.
• W2000620661 cites W2137496285 @default.
• W2000620661 cites W2154033753 @default.
• W2000620661 doi "https://doi.org/10.1084/jem.177.6.1643" @default.
• W2000620661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2191044" @default.
• W2000620661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7684431" @default.
• W2000620661 hasPublicationYear "1993" @default.
• W2000620661 type Work @default.
• W2000620661 sameAs 2000620661 @default.
• W2000620661 citedByCount "233" @default.
• W2000620661 countsByYear W20006206612012 @default.
• W2000620661 countsByYear W20006206612013 @default.
• W2000620661 countsByYear W20006206612014 @default.
• W2000620661 countsByYear W20006206612015 @default.
• W2000620661 countsByYear W20006206612016 @default.
• W2000620661 countsByYear W20006206612017 @default.
• W2000620661 countsByYear W20006206612018 @default.
• W2000620661 countsByYear W20006206612019 @default.
• W2000620661 countsByYear W20006206612020 @default.
• W2000620661 countsByYear W20006206612021 @default.
• W2000620661 countsByYear W20006206612022 @default.
• W2000620661 crossrefType "journal-article" @default.
• W2000620661 hasAuthorship W2000620661A5003314954 @default.
• W2000620661 hasAuthorship W2000620661A5026609346 @default.
• W2000620661 hasAuthorship W2000620661A5044768554 @default.
• W2000620661 hasAuthorship W2000620661A5050919306 @default.
• W2000620661 hasAuthorship W2000620661A5057922195 @default.
• W2000620661 hasAuthorship W2000620661A5085281093 @default.
• W2000620661 hasAuthorship W2000620661A5089839640 @default.
• W2000620661 hasBestOaLocation W20006206611 @default.
• W2000620661 hasConcept C100701293 @default.
• W2000620661 hasConcept C147483822 @default.
• W2000620661 hasConcept C154317977 @default.
• W2000620661 hasConcept C188280979 @default.
• W2000620661 hasConcept C19317047 @default.
• W2000620661 hasConcept C195616568 @default.
• W2000620661 hasConcept C200315206 @default.
• W2000620661 hasConcept C202751555 @default.
• W2000620661 hasConcept C203014093 @default.
• W2000620661 hasConcept C207936829 @default.
• W2000620661 hasConcept C2776090121 @default.
• W2000620661 hasConcept C2992881475 @default.
• W2000620661 hasConcept C39347974 @default.
• W2000620661 hasConcept C54355233 @default.
• W2000620661 hasConcept C59822182 @default.
• W2000620661 hasConcept C67662055 @default.
• W2000620661 hasConcept C81444415 @default.
• W2000620661 hasConcept C83464605 @default.
• W2000620661 hasConcept C86803240 @default.
• W2000620661 hasConcept C8891405 @default.
• W2000620661 hasConceptScore W2000620661C100701293 @default.
• W2000620661 hasConceptScore W2000620661C147483822 @default.
• W2000620661 hasConceptScore W2000620661C154317977 @default.
• W2000620661 hasConceptScore W2000620661C188280979 @default.
• W2000620661 hasConceptScore W2000620661C19317047 @default.
• W2000620661 hasConceptScore W2000620661C195616568 @default.
• W2000620661 hasConceptScore W2000620661C200315206 @default.
• W2000620661 hasConceptScore W2000620661C202751555 @default.
• W2000620661 hasConceptScore W2000620661C203014093 @default.
• W2000620661 hasConceptScore W2000620661C207936829 @default.
• W2000620661 hasConceptScore W2000620661C2776090121 @default.
• W2000620661 hasConceptScore W2000620661C2992881475 @default.
• W2000620661 hasConceptScore W2000620661C39347974 @default.
• W2000620661 hasConceptScore W2000620661C54355233 @default.
• W2000620661 hasConceptScore W2000620661C59822182 @default.
• W2000620661 hasConceptScore W2000620661C67662055 @default.
• W2000620661 hasConceptScore W2000620661C81444415 @default.
• W2000620661 hasConceptScore W2000620661C83464605 @default.

• next