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- W2000621285 abstract "The disposition of 2-sec-butyl-4,6-dinitrophenol (dinoseb) was determined in pregnant mice after ip or oral administration. Plasma levels of dinoseb were determined colorimetrically and isotopically, and dinoseb was separated from its metabolites in tissues by methyl ethyl ketone extraction. Dinoseb was found in all maternal tissues and was shown to cross the placenta, although a barrier was clearly present since embryo levels never exceeded 2·5% of maternal plasma levels. The rate of absorption of dinoseb was 40 times greater after ip than after oral administration. Elimination was first order, but the rate was dependent on the route, the ke being 0·02 and 0·09 hr−1 after oral and ip administration, respectively. Pregnant mice excreted dinoseb in urine and faeces regardless of the route of administration, and metabolites, which were not identified, were found in maternal liver and kidney and in the embryo, but not in maternal blood. While embryonic levels of dinoseb were similar in both cases, peak levels were reached much earlier after ip than after oral administration (8 min and 12 hr respectively), and the initial levels of the herbicide and its metabolites in the embryos were higher after ip administration. These differences may be responsible for the observed teratogenicity and embryotoxicity of dinoseb following ip but not oral administration." @default.
- W2000621285 created "2016-06-24" @default.
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- W2000621285 date "1973-02-01" @default.
- W2000621285 modified "2023-09-26" @default.
- W2000621285 title "Disposition of 2-sec-butyl-4,6-dinitrophenol (dinoseb) in pregnant mice" @default.
- W2000621285 cites W1964481754 @default.
- W2000621285 cites W2417507534 @default.
- W2000621285 doi "https://doi.org/10.1016/0015-6264(73)90060-6" @default.
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