FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000621944> ?p ?o ?g. }

• W2000621944 endingPage "215" @default.
• W2000621944 startingPage "211" @default.
• W2000621944 abstract "Replication licensing factor (RLF) is an essential initiation factor that can prevent re-replication of DNA in a single cell cycle [1Blow JJ Laskey RA A role for the nuclear envelope in controlling DNA replication within the cell cycle.Nature. 1988; 332: 546-548Crossref PubMed Scopus (464) Google Scholar, 2Tada S Blow J The replication licensing system.Biol Chem. 1998; 379: 941-949PubMed Google Scholar]. It is required for the initiation of DNA replication, binds to chromatin early in the cell cycle, is removed from chromatin as DNA replicates and is unable to re-bind replicated chromatin until the following mitosis. Chromatography of RLF from Xenopus extracts has shown that it consists of two components termed RLF-B and RLF-M [[3]Chong JPJ Mahbubani MH Khoo C-Y Blow JJ Purification of an Mcm-containing complex as a component of the DNA replication licensing system.Nature. 1995; 375: 418-421Crossref PubMed Scopus (316) Google Scholar]. The RLF-M component consists of complexes of all six Xenopus minichromosome maintenance (MCM/P1) proteins (XMcm2–7), which bind to chromatin in late mitosis and are removed as replication occurs [3Chong JPJ Mahbubani MH Khoo C-Y Blow JJ Purification of an Mcm-containing complex as a component of the DNA replication licensing system.Nature. 1995; 375: 418-421Crossref PubMed Scopus (316) Google Scholar, 4Kubota Y Mimura S Nishimoto S Takisawa H Nojima H Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor.Cell. 1995; 81: 601-609Abstract Full Text PDF PubMed Scopus (243) Google Scholar, 5Madine MA Khoo C-Y Mills AD Laskey RA MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells.Nature. 1995; 375: 421-424Crossref PubMed Scopus (232) Google Scholar, 6Thömmes P Kubota Y Takisawa H Blow JJ The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides.EMBO J. 1997; 16: 3312-3319Crossref PubMed Scopus (117) Google Scholar, 7Kubota Y Mimura S Nishimoto S Masuda T Nojima H Takisawa H Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs.EMBO J. 1997; 16: 3320-3331Crossref PubMed Scopus (94) Google Scholar]. The identity of RLF-B is currently unknown. At least two factors must be present on chromatin before licensing can occur: the Xenopus origin recognition complex (XORC) [8Carpenter PB Mueller PR Dunphy WG Role for a Xenopus Orc2-related protein in controlling DNA replication.Nature. 1996; 379: 357-360Crossref PubMed Scopus (175) Google Scholar, 9Rowles A Chong JP Brown L Howell M Evan GI Blow JJ Interaction between the origin recognition complex and the replication licensing system in Xenopus.Cell. 1996; 87: 287-296Abstract Full Text Full Text PDF PubMed Scopus (215) Google Scholar] and Xenopus Cdc6 (XCdc6) [[10]Coleman TR Carpenter PB Dunphy WG The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts.Cell. 1996; 87: 53-63Abstract Full Text Full Text PDF PubMed Scopus (328) Google Scholar]. XORC saturates Xenopus sperm chromatin at approximately one copy per replication origin whereas XCdc6 binds to chromatin only if XORC is bound first [9Rowles A Chong JP Brown L Howell M Evan GI Blow JJ Interaction between the origin recognition complex and the replication licensing system in Xenopus.Cell. 1996; 87: 287-296Abstract Full Text Full Text PDF PubMed Scopus (215) Google Scholar, 10Coleman TR Carpenter PB Dunphy WG The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts.Cell. 1996; 87: 53-63Abstract Full Text Full Text PDF PubMed Scopus (328) Google Scholar, 11Romanowski P Madine MA Rowles A Blow JJ Laskey RA The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin.Curr Biol. 1996; 6: 1416-1425Abstract Full Text Full Text PDF PubMed Scopus (172) Google Scholar]. Although XORC has been shown to be a distinct activity from RLF-B [[9]Rowles A Chong JP Brown L Howell M Evan GI Blow JJ Interaction between the origin recognition complex and the replication licensing system in Xenopus.Cell. 1996; 87: 287-296Abstract Full Text Full Text PDF PubMed Scopus (215) Google Scholar], the relationship between XCdc6 and RLF-B is currently unclear. Here, we show that active XCdc6 is loaded onto chromatin in extracts with defective RLF, and that both RLF-M and RLF-B are still required for the licensing of XCdc6-containing chromatin. Furthermore, RLF-B can be separated from XCdc6 by immunoprecipitation and standard chromatography. These experiments demonstrate that RLF-B is both functionally and physically distinct from XCdc6, and that XCdc6 is loaded onto chromatin before RLF-B function is executed." @default.
• W2000621944 created "2016-06-24" @default.
• W2000621944 creator A5012587940 @default.
• W2000621944 creator A5017566265 @default.
• W2000621944 creator A5024672425 @default.
• W2000621944 creator A5043795759 @default.
• W2000621944 date "1999-02-01" @default.
• W2000621944 modified "2023-10-11" @default.
• W2000621944 title "The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin" @default.
• W2000621944 cites W1855160608 @default.
• W2000621944 cites W1988254015 @default.
• W2000621944 cites W1991582474 @default.
• W2000621944 cites W1995594264 @default.
• W2000621944 cites W2012931476 @default.
• W2000621944 cites W2018782003 @default.
• W2000621944 cites W2085266985 @default.
• W2000621944 cites W2091038230 @default.
• W2000621944 cites W2156787082 @default.
• W2000621944 cites W2161079849 @default.
• W2000621944 cites W2161533283 @default.
• W2000621944 cites W4242753923 @default.
• W2000621944 cites W4379533959 @default.
• W2000621944 doi "https://doi.org/10.1016/s0960-9822(99)80092-x" @default.
• W2000621944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3604811" @default.
• W2000621944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10074431" @default.
• W2000621944 hasPublicationYear "1999" @default.
• W2000621944 type Work @default.
• W2000621944 sameAs 2000621944 @default.
• W2000621944 citedByCount "36" @default.
• W2000621944 countsByYear W20006219442017 @default.
• W2000621944 countsByYear W20006219442021 @default.
• W2000621944 crossrefType "journal-article" @default.
• W2000621944 hasAuthorship W2000621944A5012587940 @default.
• W2000621944 hasAuthorship W2000621944A5017566265 @default.
• W2000621944 hasAuthorship W2000621944A5024672425 @default.
• W2000621944 hasAuthorship W2000621944A5043795759 @default.
• W2000621944 hasBestOaLocation W20006219441 @default.
• W2000621944 hasConcept C104317684 @default.
• W2000621944 hasConcept C104690221 @default.
• W2000621944 hasConcept C1491633281 @default.
• W2000621944 hasConcept C151158763 @default.
• W2000621944 hasConcept C153911025 @default.
• W2000621944 hasConcept C175193931 @default.
• W2000621944 hasConcept C175248279 @default.
• W2000621944 hasConcept C188036394 @default.
• W2000621944 hasConcept C2779535977 @default.
• W2000621944 hasConcept C2780091387 @default.
• W2000621944 hasConcept C29537977 @default.
• W2000621944 hasConcept C41141232 @default.
• W2000621944 hasConcept C54266558 @default.
• W2000621944 hasConcept C54355233 @default.
• W2000621944 hasConcept C552990157 @default.
• W2000621944 hasConcept C58337764 @default.
• W2000621944 hasConcept C73573662 @default.
• W2000621944 hasConcept C83640560 @default.
• W2000621944 hasConcept C86803240 @default.
• W2000621944 hasConcept C93304396 @default.
• W2000621944 hasConcept C95444343 @default.
• W2000621944 hasConcept C98086919 @default.
• W2000621944 hasConceptScore W2000621944C104317684 @default.
• W2000621944 hasConceptScore W2000621944C104690221 @default.
• W2000621944 hasConceptScore W2000621944C1491633281 @default.
• W2000621944 hasConceptScore W2000621944C151158763 @default.
• W2000621944 hasConceptScore W2000621944C153911025 @default.
• W2000621944 hasConceptScore W2000621944C175193931 @default.
• W2000621944 hasConceptScore W2000621944C175248279 @default.
• W2000621944 hasConceptScore W2000621944C188036394 @default.
• W2000621944 hasConceptScore W2000621944C2779535977 @default.
• W2000621944 hasConceptScore W2000621944C2780091387 @default.
• W2000621944 hasConceptScore W2000621944C29537977 @default.
• W2000621944 hasConceptScore W2000621944C41141232 @default.
• W2000621944 hasConceptScore W2000621944C54266558 @default.
• W2000621944 hasConceptScore W2000621944C54355233 @default.
• W2000621944 hasConceptScore W2000621944C552990157 @default.
• W2000621944 hasConceptScore W2000621944C58337764 @default.
• W2000621944 hasConceptScore W2000621944C73573662 @default.
• W2000621944 hasConceptScore W2000621944C83640560 @default.
• W2000621944 hasConceptScore W2000621944C86803240 @default.
• W2000621944 hasConceptScore W2000621944C93304396 @default.
• W2000621944 hasConceptScore W2000621944C95444343 @default.
• W2000621944 hasConceptScore W2000621944C98086919 @default.
• W2000621944 hasIssue "4" @default.
• W2000621944 hasLocation W20006219441 @default.
• W2000621944 hasLocation W20006219442 @default.
• W2000621944 hasLocation W20006219443 @default.
• W2000621944 hasOpenAccess W2000621944 @default.
• W2000621944 hasPrimaryLocation W20006219441 @default.
• W2000621944 hasRelatedWork W1557486494 @default.
• W2000621944 hasRelatedWork W2038164592 @default.
• W2000621944 hasRelatedWork W2086995149 @default.
• W2000621944 hasRelatedWork W2087013595 @default.
• W2000621944 hasRelatedWork W2107073425 @default.
• W2000621944 hasRelatedWork W2111275137 @default.
• W2000621944 hasRelatedWork W2144021776 @default.
• W2000621944 hasRelatedWork W2368193018 @default.
• W2000621944 hasRelatedWork W2912056503 @default.
• W2000621944 hasRelatedWork W3134744679 @default.
• W2000621944 hasVolume "9" @default.

• next