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• W2000622322 abstract "Aim X-ray contrast media (CM) can cause acute kidney injury (AKI). Medullary hypoxia is pivotal in CM-induced AKI, as indicated by invasively and pin-point measured tissue oxygenation. MRI provides spatially resolved blood oxygenation level–dependent data using T2* and T2 mapping. We studied CM effects on renal T2*/T2 and benchmarked them against short periods of hyperoxia, hypoxia and aortic occlusion (AO). Methods Rats were equipped with carotid artery catheters (tip towards aorta) and supra-renal aortic occluders. T2*/T2 mapping was performed using a 9.4-T animal scanner. CM (1.5 mL iodixanol) was injected into the thoracic aorta with the animal in the scanner followed by 2 h of T2*/T2 mapping. For T2*/T2 assessment, regions of interest in the cortex (C), outer medulla (OM), inner medulla (IM) and papilla (P) were determined according to morphological features. Results Hyperoxia increased T2* in C (by 17%) and all medullary layers (25–35%). Hypoxia decreased T2* in C (40%) and all medullary layers (55–60%). AO decreased T2* in C (18%) and all medullary layers (30–40%). Upon injection of CM, T2* increased transiently, then decreased, reaching values 10–20% below baseline in C and OM and 30–40% below baseline in IM and P. Conclusion T2* mapping corroborates data previously obtained with invasive methods and demonstrates that CM injection affects renal medullary oxygenation. CM-induced T2* decrease in OM was small vs. hypoxia and aortic occlusion. T2* decrease obtained for hypoxia was more pronounced than for AO. This indicates that T2* may not accurately reflect blood oxygenation under certain conditions." @default.
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• W2000622322 date "2013-04-12" @default.
• W2000622322 modified "2023-10-11" @default.
• W2000622322 title "Early effects of an x-ray contrast medium on renal T₂*/T₂MRI as compared to short-term hyperoxia, hypoxia and aortic occlusion in rats" @default.
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• W2000622322 doi "https://doi.org/10.1111/apha.12094" @default.
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