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- W2000623176 abstract "The relation of the adrenal steroidogenesis in the responsiveness of patients with metastatic breast cancer to endocrine ablation was investigated using both perfusion of the gland in situ, and continuous peripheral infusion of pregnenolone. The results obtained by both techniques indicated that unresponsive patients converted a smaller proportion of pregnenolone to androgens relative to cortisol. Furthermore, the differences in the relative rates of synthesis were not due to abnormalities in the production or metabolic clearance rate of the precursor. The ability of the primary breast tumours to synthesize hormones and thus become independent of the hormonal environment was investigated by both the perfusion of the human breast in situ and the incubation of the neoplasm in vitro. It was observed that the tumours were capable of converting pregnenolone and dehydroepiandrosterone to progesterone and androstenedione, respectively. Inability of these neoplasms to convert cholesterol to pregnenolone indicates that the tumours rely on a continuous supply of precursors." @default.
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- W2000623176 date "1975-05-01" @default.
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- W2000623176 title "Hormonal imbalance in breast cancer" @default.
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- W2000623176 doi "https://doi.org/10.1016/0022-4731(75)90061-8" @default.
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