FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000623566> ?p ?o ?g. }

• W2000623566 endingPage "1064" @default.
• W2000623566 startingPage "1049" @default.
• W2000623566 abstract "The vitreous humor liquefies with age and readily sloshes during eye motion. The objective was to develop a computational model to determine the effect of sloshing on intravitreal drug transport for transscleral and intra-vitreal drug sources at various locations A finite element model based on a telescopic implicit envelope tracking scheme was developed to model drug dispersion. Flow velocities due to saccadic oscillations were solved for and were used to simulate drug dispersion. Saccades induced a three-dimensional flow field that indicates intense drug dispersion in the vitreous. Model results showed that the time scale for transport decreased for the sloshing vitreous when compared to static vitreous. Macular concentrations for the sloshing vitreous were found be much higher than that for the static vitreous. For low viscosities the position of the intravitreal source did not have a big impact on drug distribution. Model results show that care should be taken when extrapolating animal data, which are mostly done on intact vitreous, to old patients whose vitreous might be a liquid. The decrease in drug transport time scales and changes in localized concentrations should be considered when deciding on treatment modalities and dosing strategies." @default.
• W2000623566 created "2016-06-24" @default.
• W2000623566 creator A5062712899 @default.
• W2000623566 creator A5079970279 @default.
• W2000623566 date "2011-01-22" @default.
• W2000623566 modified "2023-10-16" @default.
• W2000623566 title "Contribution of Saccadic Motion to Intravitreal Drug Transport: Theoretical Analysis" @default.
• W2000623566 cites W114940910 @default.
• W2000623566 cites W139580965 @default.
• W2000623566 cites W1492861575 @default.
• W2000623566 cites W1973827309 @default.
• W2000623566 cites W1975986764 @default.
• W2000623566 cites W1980673089 @default.
• W2000623566 cites W1984765863 @default.
• W2000623566 cites W1998968802 @default.
• W2000623566 cites W2001016880 @default.
• W2000623566 cites W2001733471 @default.
• W2000623566 cites W2002152165 @default.
• W2000623566 cites W2013432109 @default.
• W2000623566 cites W2017279336 @default.
• W2000623566 cites W2021158612 @default.
• W2000623566 cites W2028734433 @default.
• W2000623566 cites W2029357604 @default.
• W2000623566 cites W2040236977 @default.
• W2000623566 cites W2058120142 @default.
• W2000623566 cites W2061676642 @default.
• W2000623566 cites W2062588316 @default.
• W2000623566 cites W2073897969 @default.
• W2000623566 cites W2076907122 @default.
• W2000623566 cites W2084664469 @default.
• W2000623566 cites W2085541943 @default.
• W2000623566 cites W2089692083 @default.
• W2000623566 cites W2108850090 @default.
• W2000623566 cites W2112689098 @default.
• W2000623566 cites W2120165961 @default.
• W2000623566 cites W2134013812 @default.
• W2000623566 cites W2134175990 @default.
• W2000623566 cites W2399174630 @default.
• W2000623566 cites W54507679 @default.
• W2000623566 doi "https://doi.org/10.1007/s11095-010-0356-7" @default.
• W2000623566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3074012" @default.
• W2000623566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21258958" @default.
• W2000623566 hasPublicationYear "2011" @default.
• W2000623566 type Work @default.
• W2000623566 sameAs 2000623566 @default.
• W2000623566 citedByCount "30" @default.
• W2000623566 countsByYear W20006235662013 @default.
• W2000623566 countsByYear W20006235662014 @default.
• W2000623566 countsByYear W20006235662015 @default.
• W2000623566 countsByYear W20006235662016 @default.
• W2000623566 countsByYear W20006235662017 @default.
• W2000623566 countsByYear W20006235662018 @default.
• W2000623566 countsByYear W20006235662019 @default.
• W2000623566 countsByYear W20006235662020 @default.
• W2000623566 countsByYear W20006235662021 @default.
• W2000623566 countsByYear W20006235662022 @default.
• W2000623566 countsByYear W20006235662023 @default.
• W2000623566 crossrefType "journal-article" @default.
• W2000623566 hasAuthorship W2000623566A5062712899 @default.
• W2000623566 hasAuthorship W2000623566A5079970279 @default.
• W2000623566 hasBestOaLocation W20006235662 @default.
• W2000623566 hasConcept C11054436 @default.
• W2000623566 hasConcept C118487528 @default.
• W2000623566 hasConcept C120665830 @default.
• W2000623566 hasConcept C121332964 @default.
• W2000623566 hasConcept C136229726 @default.
• W2000623566 hasConcept C142784634 @default.
• W2000623566 hasConcept C153050134 @default.
• W2000623566 hasConcept C177562468 @default.
• W2000623566 hasConcept C185592680 @default.
• W2000623566 hasConcept C192562407 @default.
• W2000623566 hasConcept C2780035454 @default.
• W2000623566 hasConcept C57879066 @default.
• W2000623566 hasConcept C71924100 @default.
• W2000623566 hasConcept C98274493 @default.
• W2000623566 hasConceptScore W2000623566C11054436 @default.
• W2000623566 hasConceptScore W2000623566C118487528 @default.
• W2000623566 hasConceptScore W2000623566C120665830 @default.
• W2000623566 hasConceptScore W2000623566C121332964 @default.
• W2000623566 hasConceptScore W2000623566C136229726 @default.
• W2000623566 hasConceptScore W2000623566C142784634 @default.
• W2000623566 hasConceptScore W2000623566C153050134 @default.
• W2000623566 hasConceptScore W2000623566C177562468 @default.
• W2000623566 hasConceptScore W2000623566C185592680 @default.
• W2000623566 hasConceptScore W2000623566C192562407 @default.
• W2000623566 hasConceptScore W2000623566C2780035454 @default.
• W2000623566 hasConceptScore W2000623566C57879066 @default.
• W2000623566 hasConceptScore W2000623566C71924100 @default.
• W2000623566 hasConceptScore W2000623566C98274493 @default.
• W2000623566 hasIssue "5" @default.
• W2000623566 hasLocation W20006235661 @default.
• W2000623566 hasLocation W20006235662 @default.
• W2000623566 hasLocation W20006235663 @default.
• W2000623566 hasLocation W20006235664 @default.
• W2000623566 hasOpenAccess W2000623566 @default.
• W2000623566 hasPrimaryLocation W20006235661 @default.
• W2000623566 hasRelatedWork W1983185116 @default.
• W2000623566 hasRelatedWork W2062202252 @default.

• next