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• W2000623862 abstract "Event Abstract Back to Event Contribution of Tumor Necrosis Factor Receptor 1 to Early Cell Death in Diabetic Retinopathy G. N. Costa1*, S. Silva1, A. R. Santiago1, Joao Martins1, F. A. Ambrosio1 and P. F. Santos1 1 University of Coimbra, Center for Neuroscience and Cell Biology, Portugal Diabetic retinopathy (DR), the leading cause of blindness in the working-age group, is one of the most common complications associated with diabetes. After the onset of the disease, DR leads to a progressive loss of retinal cells and an impairment of the Blood-Retinal-Barrier (BRB). Moreover, DR seems to hold several of the defining characteristics of a neurodegenerative disease (Barber, Prog Neuropsychopharmacol Biol Psychiatry 27(2):283-90 2002) as well as of chronic inflammation. Tumor Necrosis Factor (TNF)-α, one of the major cytokines involved in inflammation and apoptosis, has been shown to mediate the inflammatory background associated with experimental diabetes and levels of this cytokine were found to be increased in rat retinas after 1 month of diabetes. This cytokine acts by binding to two distinct receptors: Tumor Necrosis Factor Receptor 1 (TNFR1) and 2 (TNFR2), being apoptosis and NF-κB pathway activation largely mediated by TNFR1 signaling. Therefore, this study focuses on the role of TNFR1 on the development of DR by mediating TNF-α-induced-retinal cell death. Using STZ-induced diabetic rats as a model, it was found that 1 month after the onset of diabetes there was a reduction in the levels of TNFR1 receptor in the retina, comparing to the control group. This finding, together with the increased TNF-α levels, supports the proposed idea that TNFR1 plays an important role in the outcome of DR. Mixed retinal cell cultures were also used and the effect of TNFR1 blockage was assessed. These cultures show a decrease in cell viability when cultured in high glucose conditions (30mM) for 7 days, used to simulate hyperglycemia. However, when TNFR1 activity was blocked the effect of high glucose on cell viability was prevented, which indicates a protection promoted by TNFR1 antagonism against high glucose-induced cell death. Taking together these results provide evidence for Tumor Necrosis Factor Receptor 1’s role promoting the early cell death observed in hyperglycemia, thus narrowing down the molecular targets responsible for triggering Diabetic Retinopathy. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Neurodegenerative Disorders Citation: Costa GN, Silva S, Santiago AR, Martins J, Ambrosio FA and Santos PF (2009). Contribution of Tumor Necrosis Factor Receptor 1 to Early Cell Death in Diabetic Retinopathy. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.106 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Aug 2009; Published Online: 10 Aug 2009. * Correspondence: G. N Costa, University of Coimbra, Center for Neuroscience and Cell Biology, Alicante, Portugal, gcosta18@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers G. N Costa S. Silva A. R Santiago Joao Martins F. A Ambrosio P. F Santos Google G. N Costa S. Silva A. R Santiago Joao Martins F. A Ambrosio P. F Santos Google Scholar G. N Costa S. Silva A. R Santiago Joao Martins F. A Ambrosio P. F Santos PubMed G. N Costa S. Silva A. R Santiago Joao Martins F. A Ambrosio P. F Santos Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2000623862 title "Contribution of Tumor Necrosis Factor Receptor 1 to Early Cell Death in Diabetic Retinopathy" @default.
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