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- W2000623971 abstract "Relaxant effects and adenosine-antagonism of 3-propylxanthine (enprofylline) and 10 different methylxanthines were examined in isolated guinea-pig tracheas. The chemical structural requirements for tracheal relaxation were found to be different from those for adenosine antagonism by the xanthine derivatives. All xanthines produced relaxation: Enprofylline was about 5 times more potent than theophylline. However, only xanthines with a methyl in the 1-position consistently antagonized the relaxant effect of adenosine. — Theophylline over a wide range of concentrations (30–900 μM) produced a concentration dependent and surmountable antagonism at nervous adenosine receptors (isolated guinea-pig myenteric-plexus preparations). The same concentrations of enprofylline were almost devoid of antagonism at these adenosine receptors. In mice theophylline (6–24 mg/kg given intraperitoneally) dose-dependently increased locomotor activity while enprofylline (2–48 mg/kg) was without effect on behaviour. “Non-blocking” xanthines such as enprofylline may be potent bronchodilators but lack many theophylline-like actions. We, therefore, forward the hypothesis that universal adenosine antagonism is both unnecessary and undesirable with xanthine antiasthmatics." @default.
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- W2000623971 date "1982-06-01" @default.
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- W2000623971 title "Differentiation between bronchodilation and universal adenosine antagonism among xanthine derivatives" @default.
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- W2000623971 doi "https://doi.org/10.1016/0024-3205(82)90292-2" @default.
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