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- W2000626022 abstract "We previously demonstrated that IGF-1 blocks glutamate-mediated death of late oligodendrocyte progenitors (OPs) by preventing Bax translocation, mitochondrial cytochrome c release and cleavage of caspases 9 and 3. Here, we demonstrate that IGF-1 prevents caspase 3 activation in late OPs when administered up to 16 h following exposure to glutamate. Moreover, late addition of IGF-1 to OPs previously exposed to toxic levels of glutamate promotes oligodendrocyte maturation as measured by myelin basic protein expression. We also demonstrate that intraventricularly administered IGF-1 retains OPs in the perinatal white matter after hypoxia-ischemia when given after insult. These results suggest that delayed administration of IGF-1 will rescue OPs in the immature white matter and promote myelination following hypoxia-ischemia." @default.
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- W2000626022 date "2007-01-01" @default.
- W2000626022 modified "2023-10-16" @default.
- W2000626022 title "Delayed IGF-1 Administration Rescues Oligodendrocyte Progenitors from Glutamate-Induced Cell Death and Hypoxic-Ischemic Brain Damage" @default.
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- W2000626022 doi "https://doi.org/10.1159/000105471" @default.
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