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• W2000626203 endingPage "281" @default.
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• W2000626203 abstract "D1- and D2-types of dopamine receptors are located separately in direct and indirect pathway striatal projection neurons (dSPNs and iSPNs). In comparison, adenosine A1-type receptors are located in both neuron classes, and adenosine A2A-type receptors show a preferential expression in iSPNs. Due to their importance for neuronal excitability, Ca2+-currents have been used as final effectors to see the function of signaling cascades associated with different G protein-coupled receptors. For example, among many other actions, D1-type receptors increase, while D2-type receptors decrease neuronal excitability by either enhancing or reducing, respectively, CaV1 Ca2+-currents. These actions occur separately in dSPNs and iSPNs. In the case of purinergic signaling, the actions of A1- and A2A-receptors have not been compared observing their actions on Ca2+-channels of SPNs as final effectors. Our hypotheses are that modulation of Ca2+-currents by A1-receptors occurs in both dSPNs and iSPNs. In contrast, iSPNs would exhibit modulation by both A1- and A2A-receptors. We demonstrate that A1-type receptors reduced Ca2+-currents in all SPNs tested. However, A2A-type receptors enhanced Ca2+-currents only in half tested neurons. Intriguingly, to observe the actions of A2A-type receptors, occupation of A1-type receptors had to occur first. However, A1-receptors decreased CaV2 Ca2+-currents, while A2A-type receptors enhanced current through CaV1 channels. Because these channels have opposing actions on cell discharge, these differences explain in part why iSPNs may be more excitable than dSPNs. It is demonstrated that intrinsic voltage-gated currents expressed in SPNs are effectors of purinergic signaling that therefore play a role in excitability." @default.
• W2000626203 created "2016-06-24" @default.
• W2000626203 creator A5036093129 @default.
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• W2000626203 date "2013-09-07" @default.
• W2000626203 modified "2023-10-16" @default.
• W2000626203 title "Modulation of Ca2+-currents by sequential and simultaneous activation of adenosine A1 and A2A receptors in striatal projection neurons" @default.
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• W2000626203 cites W1535611266 @default.
• W2000626203 cites W1551550807 @default.
• W2000626203 cites W1574839934 @default.
• W2000626203 cites W1582008664 @default.
• W2000626203 cites W1804147567 @default.
• W2000626203 cites W1911782737 @default.
• W2000626203 cites W1913276139 @default.
• W2000626203 cites W1928698500 @default.
• W2000626203 cites W1943789780 @default.
• W2000626203 cites W1963692643 @default.
• W2000626203 cites W1964140344 @default.
• W2000626203 cites W1966753073 @default.
• W2000626203 cites W1971452772 @default.
• W2000626203 cites W1971587049 @default.
• W2000626203 cites W1971797700 @default.
• W2000626203 cites W1972899771 @default.
• W2000626203 cites W1973074412 @default.
• W2000626203 cites W1973964837 @default.
• W2000626203 cites W1974100733 @default.
• W2000626203 cites W1980552142 @default.
• W2000626203 cites W1981656407 @default.
• W2000626203 cites W1989650181 @default.
• W2000626203 cites W1991304179 @default.
• W2000626203 cites W1991864133 @default.
• W2000626203 cites W2002369676 @default.
• W2000626203 cites W2007620493 @default.
• W2000626203 cites W2010485061 @default.
• W2000626203 cites W2012568607 @default.
• W2000626203 cites W2016267039 @default.
• W2000626203 cites W2016459922 @default.
• W2000626203 cites W2017035445 @default.
• W2000626203 cites W2022233762 @default.
• W2000626203 cites W2027461525 @default.
• W2000626203 cites W2029706895 @default.
• W2000626203 cites W2031858427 @default.
• W2000626203 cites W2033564079 @default.
• W2000626203 cites W2037068086 @default.
• W2000626203 cites W2037293282 @default.
• W2000626203 cites W2040227196 @default.
• W2000626203 cites W2040259659 @default.
• W2000626203 cites W2043292527 @default.
• W2000626203 cites W2047507718 @default.
• W2000626203 cites W2047675372 @default.
• W2000626203 cites W2053124932 @default.
• W2000626203 cites W2053441706 @default.
• W2000626203 cites W2056170215 @default.
• W2000626203 cites W2063100876 @default.
• W2000626203 cites W2068153172 @default.
• W2000626203 cites W2069488037 @default.
• W2000626203 cites W2070603859 @default.
• W2000626203 cites W2071712317 @default.
• W2000626203 cites W2073684281 @default.
• W2000626203 cites W2074542206 @default.
• W2000626203 cites W2080253350 @default.
• W2000626203 cites W2080918779 @default.
• W2000626203 cites W2096024419 @default.
• W2000626203 cites W2098980699 @default.
• W2000626203 cites W2105737054 @default.
• W2000626203 cites W2106307937 @default.
• W2000626203 cites W2116851540 @default.
• W2000626203 cites W2118830830 @default.
• W2000626203 cites W2127079625 @default.
• W2000626203 cites W2137365563 @default.
• W2000626203 cites W2150107846 @default.
• W2000626203 cites W2154914042 @default.
• W2000626203 cites W2157714782 @default.
• W2000626203 cites W2161262007 @default.
• W2000626203 cites W2166561348 @default.
• W2000626203 cites W2167441016 @default.
• W2000626203 cites W2168503470 @default.
• W2000626203 cites W2169555259 @default.
• W2000626203 cites W2401952485 @default.
• W2000626203 cites W4236341500 @default.
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• W2000626203 doi "https://doi.org/10.1007/s11302-013-9386-z" @default.
• W2000626203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4040173" @default.
• W2000626203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24014158" @default.
• W2000626203 hasPublicationYear "2013" @default.
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