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- W2000626838 abstract "A series of long-chained diarylalkylimidazoles and diarylalkyltriazoles were synthesized and evaluated for the inhibitory potency for aromatase (estrogen synthetase) activity in human placental microsomes. The relative specificity of inhibition was evaluated by measuring the inhibition of cholesterol side-chain cleavage enzyme (desmolase) in human placental mitochondria and the inhibition of 7-ethoxycoumarin O-deethylase (a typical drug-metabolizing enzyme activity) in rat liver microsomes. The structural requirements including substituent effects for the strongest potency and for the highest specificity were delineated. α,ω-Diarylalkyltriazoles and imidazoles were the most interesting molecules, in which the geometric and optical isomerism displayed remarkable selectivity for aromatase inhibition." @default.
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- W2000626838 date "1981-12-01" @default.
- W2000626838 modified "2023-09-23" @default.
- W2000626838 title "Effect of heparin on the subcellular distribution of human placental 7-ethoxycoumarin O-deethylase activity" @default.
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- W2000626838 doi "https://doi.org/10.1016/0006-2952(81)90529-3" @default.
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