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- W2000627306 abstract "Three trace impurities found in 4-acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one (II), a novel antihypertensive agent, were isolated by a combination of low-pressure liquid chromatography and preparative TLC. These impurities were identified as the formate ester of II, a pyridazinone having a 2-methyl rather than the 2'-hydroxyethyl substituent, and a bis(pyridazinonyl)methane analog. In addition, the product of O-alkylation rather than of N-alkylation of 4-acetyl-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one (I) with ethylene carbonate was detected by high-performance liquid chromatography. The biological activity of these four impurities was compared to that of II." @default.
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- W2000627306 date "1981-04-01" @default.
- W2000627306 modified "2023-09-23" @default.
- W2000627306 title "Isolation and Identification of Impurities in 4-Acetyl-2-(2′-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one, an Antihypertensive Agent" @default.
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- W2000627306 doi "https://doi.org/10.1002/jps.2600700419" @default.
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